Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 4/20 | 0.30 |
| ▸ | MAOB | P27338 | 4/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8137244 | 0.93 | P2RX7 (0.34) | P2RX7CSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| Fumaric Acid SCHEMBL8142605 | 0.90 | CSNK1A1 (0.32) | P2RX7CSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| Fumaric Acid SCHEMBL8142601 | 0.90 | CSNK1A1 (0.32) | P2RX7CSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| SCHEMBL9304005 | 0.89 | P2RX7 (0.38) | P2RX7RORCMAOA | |
| Fumaric Acid SCHEMBL8138799 | 0.84 | KDM4E (0.34) | P2RX7CSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| Fumaric Acid SCHEMBL8138796 | 0.84 | KDM4E (0.34) | P2RX7CSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| SCHEMBL8134112 | 0.84 | CRHR1 (0.36) | — | |
| SCHEMBL8134219 | 0.84 | CDC7 (0.41) | P2RX7MAOAMAOBACHE | |
| SCHEMBL9305694 | 0.82 | TDP1 (0.37) | P2RX7ESR1 | |
| SCHEMBL8134084 | 0.82 | HTR2A (0.43) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296491-A | Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | claimed |