Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301520 | 0.83 | ALOX5 (0.61) | PTGS2ALOX5PTGS1KDM4EKMT2A | |
| SCHEMBL9302806 | 0.83 | ALOX5 (0.61) | PTGS2ALOX5PTGS1KDM4EKMT2A | |
| SCHEMBL28798157 | 0.74 | MEN1 (0.54) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL10312053 | 0.74 | CASP3 (0.47) | PTGS2ALOX5PTGS1TTRALDH1A1 | |
| SCHEMBL20815516 | 0.74 | CASP3 (0.47) | PTGS2ALOX5PTGS1TTRALDH1A1 | |
| SCHEMBL10123058 | 0.72 | TTR (0.47) | PTGS2ALOX5PTGS1TTRALDH1A1 | |
| SCHEMBL28850385 | 0.70 | ALDH1A1 (0.62) | PTGS2ALOX5PTGS1TTRALDH1A1 | |
| SCHEMBL19084458 | 0.70 | ALDH1A1 (0.62) | PTGS2ALOX5PTGS1TTRALDH1A1 | |
| SCHEMBL24067376 | 0.69 | CYP11B1 (0.51) | PTGS2ALOX5PTGS1ALDH1A1KDM4E | |
| SCHEMBL17972564 | 0.69 | MEN1 (0.45) | ALDH1A1HPGDKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302597-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1994-04-12 | — | — | US | claimed |
| EP-0569491-A1 | 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-11-18 | — | — | EP | claimed |
| WO-1992013536-A1 | 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-20 | — | — | WO | claimed |