Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9304831 | 1.00 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9305919 | 0.94 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9305535 | 0.94 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL9307647 | 0.94 | ADRA1D (0.65) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9305702 | 0.79 | ADRA1D (0.70) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9305855 | 0.79 | ADRA1D (0.70) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL9304961 | 0.78 | ADRA1D (0.69) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7646052 | 0.77 | HTR1A (0.68) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9539641 | 0.77 | HTR1A (0.80) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL7648139 | 0.76 | HTR1A (0.79) | ADRA1DADRA1AADRA1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332732-A | Thiophene and pyridine antipsychotic agents | MCNEILAB, INC. (US) | 1994-07-26 | — | — | US | disclosed |