SCHEMBL9305415

SCHEMBL9305415

C=CCn1c(OC)nc(N)cc1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
TSHR P16473 1/20 0.44
GRK6 P43250 1/20 0.39
GAA P10253 3/20 0.39
MAPT P10636 3/20 0.39
TDP1 Q9NUW8 3/20 0.39
APLNR P35414 1/20 0.39
FPR1 P21462 1/20 0.39
ALOX15 P16050 1/20 0.38
HSD17B10 Q99714 2/20 0.37
USP2 O75604 1/20 0.37
CYP3A4 P08684 1/20 0.36
KDM4E B2RXH2 1/20 0.36
GLA P06280 1/20 0.36
THRB P10828 1/20 0.36
HPGD P15428 1/20 0.36
HIF1A Q16665 1/20 0.36
POLB P06746 1/20 0.36
LMNA P02545 1/20 0.36
MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7041805 0.78 TNF (0.43) ALDH1A1TSHRGRK6MAPTKDM4E
SCHEMBL9303572 0.74 CYP3A4 (0.37) ALDH1A1TSHRGRK6GAAMAPT
SCHEMBL7038232 0.72 ALDH1A1 (0.37) ALDH1A1MAPTTDP1ALOX15HSD17B10
SCHEMBL6778694 0.72 PDE4D (0.35) GRK6MAPTUSP2HPGDPOLB
SCHEMBL9300556 0.72 MAPT (0.39) ALDH1A1MAPTMEN1KMT2A
SCHEMBL7040447 0.71 MAPT (0.34) ALDH1A1MAPTPOLB
SCHEMBL7038766 0.71 KDM4E (0.46) ALDH1A1TSHRMAPTTDP1ALOX15
SCHEMBL7036369 0.71 MTNR1A (0.38) ALDH1A1TSHRGRK6MAPTUSP2
SCHEMBL9501414 0.70 GRK6 (0.34) ALDH1A1TSHRGRK6GAAMAPT
SCHEMBL9304641 0.70 CDK2 (0.39) ALDH1A1TSHRGRK6GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5314890-A Treatment of asthma MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A. (IT) 1994-05-24 US disclosed
EP-0531349-A1 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION MALESCI ISTITUTO FARMACOBIOLOGICO S.p.A. (IT) 1993-03-17 EP disclosed
WO-1991017993-A1 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A (IT) 1991-11-28 WO disclosed