SCHEMBL9501414

SCHEMBL9501414

C=CCn1c(OC)nc(N=O)c(N)c1=O

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRK6 P43250 1/20 0.34
POLB P06746 1/20 0.34
CYP3A4 P08684 1/20 0.33
USP2 O75604 1/20 0.32
ALDH1A1 P00352 5/20 0.32
KDM4E B2RXH2 4/20 0.32
HPGD P15428 2/20 0.32
MAPT P10636 2/20 0.32
GLA P06280 2/20 0.32
GAA P10253 2/20 0.32
THRB P10828 1/20 0.32
HIF1A Q16665 1/20 0.32
TSHR P16473 1/20 0.32
HTT P42858 2/20 0.31
LMNA P02545 2/20 0.31
ADORA2B P29275 3/20 0.31
ADORA2A P29274 2/20 0.31
PDE4A P27815 1/20 0.30
PDE4B Q07343 1/20 0.30
PDE4C Q08493 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9303572 0.82 CYP3A4 (0.37) GRK6POLBCYP3A4USP2ALDH1A1
SCHEMBL9304641 0.81 CDK2 (0.39) GRK6POLBCYP3A4USP2ALDH1A1
SCHEMBL9305415 0.70 ALDH1A1 (0.44) GRK6POLBCYP3A4USP2ALDH1A1
SCHEMBL9308527 0.65 ADORA2B (0.45) POLBCYP3A4USP2ALDH1A1KDM4E
SCHEMBL9308358 0.65 ADORA2B (0.52) POLBALDH1A1MAPTADORA2BADORA2A
SCHEMBL8505340 0.62 GAA (0.42) POLBCYP3A4ALDH1A1KDM4EHPGD
SCHEMBL13217553 0.60 PIM1 (0.38) ALDH1A1MAPTGAAADORA2BSMN1; SMN2
SCHEMBL4759502 0.60 CYP3A4 (0.58) CYP3A4USP2ALDH1A1KDM4EHPGD
SCHEMBL4828458 0.59 KDM4E (0.63) POLBCYP3A4ALDH1A1KDM4EHPGD
SCHEMBL10616188 0.59 CYP3A4 (0.50) POLBCYP3A4USP2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0531349-A1 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION MALESCI ISTITUTO FARMACOBIOLOGICO S.p.A. (IT) 1993-03-17 EP claimed
WO-1991017993-A1 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A (IT) 1991-11-28 WO claimed