Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307593 | 0.91 | THRA (0.39) | GGPS1THRATHRBPTPN1MTNR1A | |
| Iodide SCHEMBL9308238 | 0.90 | THRA (0.38) | GGPS1THRATHRBPTPN1 | |
| Iodide SCHEMBL9307608 | 0.89 | CNR2 (0.46) | GGPS1KDM4EAPAF1ALDH1A1LMNA | |
| Iodide SCHEMBL9307636 | 0.84 | CNR2 (0.46) | GGPS1POLB | |
| Iodide SCHEMBL9307766 | 0.84 | PDIA6 (0.39) | THRATHRBPTPN1 | |
| Iodide SCHEMBL9305573 | 0.82 | MAPT (0.40) | GGPS1KDM4EAPAF1ALDH1A1LMNA | |
| Iodide SCHEMBL9305538 | 0.81 | CNR2 (0.45) | POLBMAPT | |
| Iodide SCHEMBL9305526 | 0.79 | KDM4E (0.38) | KDM4EAPAF1ALDH1A1LMNAPOLB | |
| Iodide SCHEMBL9306528 | 0.79 | TP53 (0.38) | GGPS1APAF1ALDH1A1LMNAMAPT | |
| Iodide SCHEMBL9307789 | 0.79 | MAPT (0.42) | KDM4EAPAF1ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |