Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306282 | 0.90 | S1PR2 (0.43) | S1PR2S1PR1S1PR3LPAR2THRA | |
| Iodide SCHEMBL9306668 | 0.89 | ALDH1A1 (0.42) | S1PR2S1PR1S1PR3LPAR2THRA | |
| Iodide SCHEMBL9305687 | 0.88 | S1PR2 (0.42) | S1PR2S1PR1S1PR3LPAR2THRA | |
| Iodide SCHEMBL9306262 | 0.87 | TAS2R14 (0.48) | ALDH1A1LMNATSHRHTTSMN1; SMN2 | |
| Iodide SCHEMBL9307236 | 0.86 | THRA (0.42) | THRATHRB | |
| Iodide SCHEMBL9309555 | 0.86 | S1PR2 (0.43) | S1PR2S1PR1S1PR3LPAR2THRA | |
| Iodide SCHEMBL9305668 | 0.85 | S1PR2 (0.42) | S1PR2S1PR1S1PR3LPAR2THRA | |
| Iodide SCHEMBL9306404 | 0.83 | THRA (0.44) | THRATHRB | |
| Iodide SCHEMBL9306143 | 0.80 | S1PR2 (0.41) | S1PR2S1PR1S1PR3LPAR2THRA | |
| Iodide SCHEMBL9305255 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |