Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198243 | 0.94 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1POLBHTTHSD17B10 | |
| SCHEMBL11674331 | 0.87 | — | — | |
| SCHEMBL26865867 | 0.82 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1POLBHTTHSD17B10 | |
| SCHEMBL55591 | 0.81 | L3MBTL1 (0.61) | L3MBTL1ALDH1A1POLBHTTHSD17B10 | |
| SCHEMBL14811830 | 0.81 | L3MBTL1 (0.61) | L3MBTL1ALDH1A1POLBHTTHSD17B10 | |
| SCHEMBL14812115 | 0.81 | L3MBTL1 (0.61) | L3MBTL1ALDH1A1POLBHTTHSD17B10 | |
| SCHEMBL30693669 | 0.79 | L3MBTL1 (0.59) | L3MBTL1ALDH1A1POLBHTTHSD17B10 | |
| SCHEMBL27774970 | 0.79 | L3MBTL1 (0.59) | L3MBTL1ALDH1A1POLBHTTHSD17B10 | |
| SCHEMBL2789189 | 0.79 | L3MBTL1 (0.54) | L3MBTL1ALDH1A1POLBHTTHSD17B10 | |
| SCHEMBL3447071 | 0.77 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1POLBHTTCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376449-B2 | Indole carboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2016-06-28 | — | — | US | disclosed |
| US-20150203505-A1 | INDOLE CARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2015-07-23 | — | — | US | disclosed |
| US-8633319-B2 | 7-(1H-pyrazol-4-yl)-1,6-naphthyridine compounds as Syk inhibitors | GLAXO GROUP LIMITED (GB) | 2014-01-21 | — | — | US | disclosed |
| US-20130040984-A1 | 7-(lH-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-02-14 | — | — | US | disclosed |
| WO-1994024865-A1 | METHODS FOR CONTROLLING FLOWERING IN PLANTS | THE REGENTS OF THE UNIVERSTIY OF CALIFORNIA (US) | 1994-11-10 | — | — | WO | disclosed |
| US-5300481-A | Applying serotonin, malatonin and derivatives with surfactant | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-04-05 | — | — | US | disclosed |
| EP-0281242-B1 | BETA-ALKYLMELATONINS | ELI LILLY AND COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |
| CN-1017426-B | Process for preparing alkyl melatonin | LILLY CO ELI (US) | 1992-07-15 | — | — | CN | disclosed |
| US-4997845-A | β-alkylmelatonins as ovulation inhibitors | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0281242-A1 | Beta-alkylmelatonins | ELI LILLY AND COMPANY (US) | 1988-09-07 | — | — | EP | disclosed |
| CN-88100478-A | alkyl melatonin | — | 1988-08-17 | — | — | CN | disclosed |
| US-4614807-A | ANTIFERTILITY AGENTS | ELI LILLY AND COMPANY (US) | 1986-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040984-A1 | 7-(lH-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS | SYK, BTK, LYN | L3MBTL1 1389/4885ALDH1A1 2588/4885POLB 4453/4885 |
| US-20150203505-A1 | INDOLE CARBOXAMIDE DERIVATIVE | MTNR1A, MTNR1B, IDO2 | L3MBTL1 2504/4885ALDH1A1 383/4885POLB 4560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.