Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307766 | 0.91 | PDIA6 (0.39) | THRATHRBAPLNRPDIA6PTPN1 | |
| Iodide SCHEMBL9307421 | 0.91 | GGPS1 (0.38) | THRATHRBPTPN1MTNR1AGGPS1 | |
| Iodide SCHEMBL9305538 | 0.88 | CNR2 (0.45) | — | |
| Iodide SCHEMBL9308238 | 0.85 | THRA (0.38) | THRATHRBPDIA6PTPN1GGPS1 | |
| Iodide SCHEMBL9307608 | 0.80 | CNR2 (0.46) | GGPS1 | |
| Iodide SCHEMBL9308058 | 0.79 | CNR2 (0.46) | — | |
| Iodide SCHEMBL9307841 | 0.79 | POLB (0.43) | THRATHRB | |
| Iodide SCHEMBL9306247 | 0.77 | S1PR2 (0.42) | THRATHRBNPC1RAB9A | |
| Iodide SCHEMBL9306470 | 0.77 | S1PR2 (0.42) | THRATHRBNPC1RAB9A | |
| Iodide SCHEMBL9305668 | 0.77 | S1PR2 (0.42) | THRATHRBAPLNRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |