Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RRM1 | P23921 | 1/20 | 0.35 |
| ▸ | CASP2 | P42575 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9802585 | 0.95 | EPHX1 (0.41) | NOD1DPP7EPHX1TLR2NAAA | |
| SCHEMBL8055730 | 0.95 | EPHX1 (0.41) | NOD1DPP7EPHX1TLR2NAAA | |
| SCHEMBL248427 | 0.93 | EPHX1 (0.44) | NOD1DPP7EPHX1TLR2NAAA | |
| SCHEMBL248429 | 0.93 | EPHX1 (0.44) | NOD1DPP7EPHX1TLR2NAAA | |
| Phosphoric Acid SCHEMBL8213494 | 0.87 | ANPEP (0.44) | NOD1EPHX1TLR2NAAAKDM4E | |
| SCHEMBL2282993 | 0.82 | NOD1 (0.48) | NOD1EPHX1NAAAKDM4EALDH1A1 | |
| SCHEMBL7342396 | 0.82 | CA1 (0.44) | ALOX15NOD1DPP7EPHX1CA1 | |
| SCHEMBL2282988 | 0.82 | NOD1 (0.48) | NOD1EPHX1NAAAKDM4EALDH1A1 | |
| SCHEMBL14367745 | 0.82 | CA1 (0.44) | ALOX15NOD1DPP7EPHX1CA1 | |
| SCHEMBL21206958 | 0.81 | TGFBR1 (0.36) | TLR2KDM4ECA1CA2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5347007-A | Mesylated hydroxymethyl compound treated with alkali metal chloride or quaternary ammonium chloride to form chloromethylamide compound | E. R. SQUIBB & SONS, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5260448-A | Treating a vinyl bromide containing compound with a metal carbonate cyclizing agent | E. R. SQUIBB & SONS, INC. (US) | 1993-11-09 | — | — | US | disclosed |
| US-5260449-A | Method for preparing 7-oxabicycloheptyl substituted bromooxazole amide prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds | E. R. SQUIBB & SONS, INC. (US) | 1993-11-09 | — | — | US | disclosed |