Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 10/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RRM1 | P23921 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9802585 | 1.00 | EPHX1 (0.41) | EPHX1DPP7NOD1NAAATLR2 | |
| SCHEMBL248427 | 0.98 | EPHX1 (0.44) | EPHX1DPP7NOD1NAAATLR2 | |
| SCHEMBL248429 | 0.98 | EPHX1 (0.44) | EPHX1DPP7NOD1NAAATLR2 | |
| Oxalic Acid SCHEMBL9307684 | 0.95 | ALOX15 (0.44) | EPHX1DPP7NOD1NAAATLR2 | |
| Phosphoric Acid SCHEMBL8213494 | 0.92 | ANPEP (0.44) | EPHX1NOD1NAAATLR2KDM4E | |
| SCHEMBL14367745 | 0.86 | CA1 (0.44) | EPHX1DPP7NOD1CA1CA2 | |
| SCHEMBL7342396 | 0.86 | CA1 (0.44) | EPHX1DPP7NOD1CA1CA2 | |
| SCHEMBL21206958 | 0.86 | TGFBR1 (0.36) | TLR2CA1CA2KDM4E | |
| SCHEMBL7355950 | 0.83 | NOD1 (0.40) | EPHX1DPP7NOD1CA1CA2 | |
| SCHEMBL26225624 | 0.83 | NOD1 (0.46) | EPHX1DPP7NOD1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114534-A | REACTING A KETONE DERIVATIVE OF CARBAMOYL SUBSTITUTED HETEROCYCLE WITH PHOSPHORANE, FOLLOWED BY ACIDIFICATION TO FORM AN ANTICOAGULANT | ELI LILLY AND COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| US-6075147-A | OMEGA-PHENYL-OMEGA-(3-PYRIDYL)-OMEGA-ALKENOIC ACID DERIVATIVES BEARING A CARBAMOYL SUBSTITUTED OXAZOLYL OR OXAZOLINYL GROUP ON THE PHENYL RING IS USEFUL FOR THROMBOXANE RECEPTOR ANTAGONSIM OR THROMBOXANE SYNTHASE INHIBITOR | ELI LILLY AND COMPANY (US) | 2000-06-13 | — | — | US | disclosed |
| US-6031095-A | Intermediates in the preparation of substituted alkenoic acids | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-5990308-A | Intermediates in the preparation of substituted alkenoic acids | ELI LILLY AND COMPANY (US) | 1999-11-23 | — | — | US | disclosed |
| US-5849766-A | Carbamoyl substituted heterocycles | ELI LILLY AND COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| US-5849922-A | Preparation of substituted alkenoic acids | ELI LILLY AND COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0816361-A2 | Preparation of substituted alkenoic acids | ELI LILLY AND COMPANY (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0811621-A2 | Carbamoyl substituted oxazoles as thromboxane receptor antagonists | ELI LILLY AND COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5618946-A | 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| US-5539126-A | PROSTAGLANDIN ANALOGS, THROMBOXANE A2 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-07-23 | — | — | US | disclosed |
| EP-0678507-A1 | Method for preparing homochiral maleimide intermediates, via silylation techniques, used in the enantioselective preparation of anti-thrombotic and anti-vasospastic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-10-25 | — | — | EP | disclosed |
| US-5436347-A | Benzaldehyde intermediates useful in the preparation of 7-oxabicycloheptane carboxylic acid prostaglandin analog anti-thrombotic and anti-vasospastic compounds and method for preparing same | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| US-5399725-A | Forming alcohol-amides by reacting a 7-oxabicycloheptane imide with a 2-/2-metallated phenyl/-1,3-dioxolane /metal is lithium or magnesium bromide/ and reducing the product | BRISTOL-MYERS SQUIBB CO. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0626384-A1 | 7-Oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of antithrombotic and anti-vasospastic compounds and method for preparing same | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5347007-A | Mesylated hydroxymethyl compound treated with alkali metal chloride or quaternary ammonium chloride to form chloromethylamide compound | E. R. SQUIBB & SONS, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5332840-A | Acylation an anhydride and reaction with oxazolidine to form benzaldehyde | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-07-26 | — | — | US | disclosed |
| US-5281716-A | Enzyme inhibitors for anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0575069-A1 | Method for preparing 7-oxabicycloheptyl substituted oxazole amide prostaglandin analog intermediates useful in the preparation of antithrombotic and anti-vasospastic compounds | E.R. Squibb & Sons, Inc. (US) | 1993-12-22 | — | — | EP | disclosed |
| US-5260448-A | Treating a vinyl bromide containing compound with a metal carbonate cyclizing agent | E. R. SQUIBB & SONS, INC. (US) | 1993-11-09 | — | — | US | disclosed |
| US-5260449-A | Method for preparing 7-oxabicycloheptyl substituted bromooxazole amide prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds | E. R. SQUIBB & SONS, INC. (US) | 1993-11-09 | — | — | US | disclosed |