SCHEMBL930786

SCHEMBL930786

C[C@@]1(F)[C@H](OC(=O)c2ccccc2)[C@@H](COC(=O)c2ccccc2)O[C@H]1n1cnc2c(Cl)nc(N)nc21

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NT5E P21589 3/20 0.44
HINT1 P49773 2/20 0.41
LMNA P02545 2/20 0.40
ALDH1A1 P00352 1/20 0.40
TP53 P04637 1/20 0.40
MAPT P10636 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PNP P00491 1/20 0.38
P2RY11 Q96G91 1/20 0.38
ADORA2A P29274 1/20 0.37
ABCB1 P08183 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL930787 1.00 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53
SCHEMBL930789 1.00 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53
SCHEMBL6365090 1.00 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53
SCHEMBL30378647 1.00 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53
SCHEMBL19777955 1.00 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53
SCHEMBL24829628 1.00 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53
SCHEMBL14652919 1.00 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53
SCHEMBL17453217 1.00 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53
SCHEMBL2484115 0.94 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53
SCHEMBL2484116 0.94 NT5E (0.44) NT5EHINT1LMNAALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 165 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4667053-A2 BETA-D-2'-DEOXY-2'ALPHA-FLUORO-2'-BETA-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT ATEA Pharmaceuticals, Inc. (US) 2025-12-24 EP disclosed
EP-3265102-B1 BETA-D-2'-DEOXY-2'ALPHA-FLUORO-2'-BETA-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT ATEA PHARMACEUTICALS INC (US) 2025-08-20 EP disclosed
US-20250243235-A1 Beta-D-2'-DEOXY-2'-alpha-FLUORO-2'-Beta-C-SUBSTITUTED-2-MODIFIED-N6- SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT Atea Pharmaceuticals, Inc. (US) 2025-07-31 US disclosed
US-12084473-B2 β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment Atea Pharmaceuticals, Inc. (US) 2024-09-10 US disclosed
US-11975016-B2 2′-substituted-N6-substituted purine nucleotides for RNA virus treatment Atea Pharmaceuticals, Inc. (US) 2024-05-07 US disclosed
US-20240002426-A1 BETA-D-2'-DEOXY-2'-ALPHA-FLUORO-2'-BETA-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT Atea Pharmaceuticals, Inc. (US) 2024-01-04 US disclosed
US-20230310481-A1 BI- AND MONOCYCLIC NUCLEOSIDE ANALOGS FOR TREATMENT OF HEPATITIS E Janssen Pharmaceuticals, Inc. 2023-10-05 US disclosed
EP-3013340-B9 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF JANSSEN PHARMACEUTICALS INC (US) 2023-10-04 EP disclosed
EP-3013340-B1 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF JANSSEN BIOPHARMA INC (US) 2023-06-07 EP disclosed
US-20230167151-A1 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF JANSSEN PHARMACEUTICA NV (BE) 2023-06-01 US disclosed
US-20100286083-A1 NUCLEOSIDE ANALOGS PHARMASSET, INC. (US) 2010-11-11 US disclosed
US-20100279973-A1 SYNTHESIS OF PURINE NUCLEOSIDES PHARMASSET, INC. (US) 2010-11-04 US disclosed
WO-2010075554-A1 SYNTHESIS OF PURINE NUCLEOSIDES PHARMASSET, INC. (US) 2010-07-01 WO disclosed
WO-2010075549-A2 NUCLEOSIDE PHOSPHORAMIDATES PHARMASSET, INC. (US) 2010-07-01 WO disclosed
WO-2010075517-A2 NUCLEOSIDE ANALOGS PHARMASSET, INC. (US) 2010-07-01 WO disclosed
WO-2010075549-A2 NUCLEOSIDE PHOSPHORAMIDATES PHARMASSET, INC. (US) 2010-07-01 WO disclosed
US-20100081628-A1 NUCLEOSIDE CYCLICPHOSPHATES PHARMASSET, INC. (US) 2010-04-01 US disclosed
US-20100081628-A1 NUCLEOSIDE CYCLICPHOSPHATES PHARMASSET, INC. (US) 2010-04-01 US disclosed
WO-2009152095-A2 NUCLEOSIDE CYCLICPHOSPHATES PHARMASSET, INC. (US) 2009-12-17 WO disclosed
WO-2009152095-A2 NUCLEOSIDE CYCLICPHOSPHATES PHARMASSET, INC. (US) 2009-12-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100279973-A1 SYNTHESIS OF PURINE NUCLEOSIDES PNP, NUDT1, TYMP NT5E 64/4885HINT1 75/4885LMNA 1983/4885
US-20230310481-A1 BI- AND MONOCYCLIC NUCLEOSIDE ANALOGS FOR TREATMENT OF HEPATITIS E NME2, HAVCR2, NME1 NT5E 88/4885HINT1 391/4885LMNA 1088/4885
US-20230167151-A1 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF PNP, NUDT1, NT5C2 NT5E 15/4885HINT1 83/4885LMNA 2079/4885
US-12084473-B2 β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment NSUN2, PNP, NUDT1 NT5E 49/4885HINT1 497/4885LMNA 1327/4885
US-11975016-B2 2′-substituted-N6-substituted purine nucleotides for RNA virus treatment NSUN2, ADAR, NSUN3 NT5E 90/4885HINT1 296/4885LMNA 2347/4885
US-20250243235-A1 Beta-D-2'-DEOXY-2'-alpha-FLUORO-2'-Beta-C-SUBSTITUTED-2-MODIFIED-N6- SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT NSUN2, NUDT1, DCTD NT5E 62/4885HINT1 572/4885LMNA 1290/4885
US-20100081628-A1 NUCLEOSIDE CYCLICPHOSPHATES PNP, NUDT1, TYMP NT5E 51/4885HINT1 111/4885LMNA 1306/4885
US-20240002426-A1 BETA-D-2'-DEOXY-2'-ALPHA-FLUORO-2'-BETA-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT NSUN2, NUDT1, DCTD NT5E 62/4885HINT1 572/4885LMNA 1290/4885
US-20100286083-A1 NUCLEOSIDE ANALOGS PNP, SAMHD1, HAVCR2 NT5E 83/4885HINT1 136/4885LMNA 2344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.