Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.39 |
| ▸ | EDNRA | P25101 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9309667 | 0.95 | AGTR1 (0.41) | AGTR1AGTR2EDNRA | |
| SCHEMBL9310339 | 0.94 | KDM4E (0.33) | AGTR1AGTR2EDNRA | |
| SCHEMBL9311392 | 0.92 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9310369 | 0.86 | AGTR1 (0.40) | AGTR1AGTR2EDNRA | |
| SCHEMBL9859274 | 0.86 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL9309904 | 0.85 | MAPK1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL9309651 | 0.85 | AGTR2 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9309256 | 0.85 | AGTR1 (0.38) | AGTR1AGTR2EDNRA | |
| SCHEMBL9309363 | 0.85 | EDNRA (0.37) | AGTR1EDNRA | |
| SCHEMBL9859850 | 0.85 | AGTR1 (0.34) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| WO-1992020673-A1 | ANTIHYPOTENSIVE BENZOFURAN DERIVATIVES WITH N-LINKED 1H-IMIDAZOLYLMETHYL-5-CARBOXAMIDE SUBSTITUENTS | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514216-A1 | Antihypotensive benzofuran derivatives with N-linked 1H-imidazolyl-methyl-5-carboxamide substituents | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016552-A1 | 1-IMIDAZOLGEMETHYL BENZOFURAN DERIVATIVES AS INHIBITORS OF ANGIOTENSIN II ACTIVITY | GLAXO GROUP LIMITED (GB) | 1992-10-01 | — | — | WO | disclosed |
| EP-0505954-A1 | N-Imidazolylmethyl benzofuran derivatives as inhibitors of angiotensin II activity | GLAXO GROUP LIMITED (GB) | 1992-09-30 | — | — | EP | disclosed |