Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308209 | 0.94 | AGTR1 (0.39) | AGTR1AGTR2EDNRA | |
| SCHEMBL9309667 | 0.92 | AGTR1 (0.41) | AGTR1AGTR2EDNRA | |
| SCHEMBL9309904 | 0.92 | MAPK1 (0.36) | KDM4EALDH1A1AGTR1AGTR2ADORA2B | |
| SCHEMBL9710524 | 0.88 | AGTR2 (0.31) | AGTR2EDNRA | |
| SCHEMBL9308888 | 0.88 | AGTR1 (0.31) | AGTR1AGTR2ADORA2BCYP1A2CYP2C9 | |
| SCHEMBL8545688 | 0.88 | ALDH1A1 (0.38) | KDM4EALDH1A1ADORA2BSIRT3MAPK1 | |
| SCHEMBL9309949 | 0.86 | AGTR1 (0.34) | AGTR1AGTR2 | |
| SCHEMBL9311392 | 0.85 | AGTR1 (0.38) | AGTR1AGTR2MAPK1 | |
| SCHEMBL9309677 | 0.85 | MAPK1 (0.37) | KDM4EALDH1A1ADORA2BCYP1A2CYP2C9 | |
| SCHEMBL9309104 | 0.84 | MKNK2 (0.34) | AGTR1AGTR2EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| WO-1992020673-A1 | ANTIHYPOTENSIVE BENZOFURAN DERIVATIVES WITH N-LINKED 1H-IMIDAZOLYLMETHYL-5-CARBOXAMIDE SUBSTITUENTS | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514216-A1 | Antihypotensive benzofuran derivatives with N-linked 1H-imidazolyl-methyl-5-carboxamide substituents | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |