Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27949086 | 0.98 | LIPG (0.42) | TLR8LIPGHTR2ATYRMEN1 | |
| SCHEMBL31556605 | 0.98 | LIPG (0.42) | TLR8LIPGHTR2ATYRMEN1 | |
| SCHEMBL28681524 | 0.94 | TLR8 (0.39) | TLR8LIPGTYRMEN1TP53 | |
| Hydrochloric Acid SCHEMBL6049597 | 0.92 | TLR8 (0.38) | TLR8LIPGTYRMEN1MAPT | |
| SCHEMBL14335441 | 0.85 | — | — | |
| SCHEMBL21652406 | 0.79 | LIPG (0.41) | LIPGHTR2ATYRMEN1TP53 | |
| SCHEMBL9242673 | 0.78 | LIPG (0.44) | LIPGHTR2ATYRMEN1TP53 | |
| SCHEMBL722288 | 0.78 | LIPG (0.44) | LIPGHTR2ATYRMEN1TP53 | |
| SCHEMBL12610435 | 0.78 | LIPG (0.44) | LIPGHTR2ATYRMEN1TP53 | |
| SCHEMBL14267185 | 0.78 | LIPG (0.44) | LIPGHTR2ATYRMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665744-B1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIV ROCHESTER (US) | 2015-04-08 | — | — | EP | claimed |
| US-8986953-B2 | Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation | UNIVERSITY OF ROCHESTER (US) | 2015-03-24 | — | — | US | claimed |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | NATIONAL SCIENCE FOUNDATION | 2013-12-12 | — | — | US | claimed |
| EP-2665744-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2013-11-27 | — | — | EP | claimed |
| WO-2012100176-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2012-07-26 | — | — | WO | claimed |
| EP-1466015-A4 | BIOCONJUGATE-NANOPARTICLE PROBES | NANOSPHERE INC (US) | 2007-02-28 | — | — | EP | claimed |
| EP-1466015-A2 | BIOCONJUGATE-NANOPARTICLE PROBES | Nanosphere, Inc. (US) | 2004-10-13 | — | — | EP | claimed |
| WO-2003081202-A2 | BIOCONJUGATE-NANOPARTICLE PROBES | NANOSPHERE, INC. (US) | 2003-10-02 | — | — | WO | claimed |
| US-20030143598-A1 | Bioconjugate-nanoparticle probes | NANOSPHERE, INC. | 2003-07-31 | — | — | US | claimed |
| CN-113980536-B | Formaldehyde absorption emulsion and preparation method and application thereof | 万华化学集团股份有限公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-113980536-A | Formaldehyde absorbing emulsion and preparation method and application thereof | 万华化学集团股份有限公司 | 2022-01-28 | — | — | CN | disclosed |
| EP-3475277-B1 | ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF | BIOIMICS AB (SE) | 2021-10-20 | — | — | EP | disclosed |
| US-11130741-B2 | Anti-infective heterocyclic compounds and uses thereof | BIOIMICS AB (SE) | 2021-09-28 | — | — | US | disclosed |
| US-20190233384-A1 | ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF | BIOIMICS AB (SE) | 2019-08-01 | — | — | US | disclosed |
| EP-1401441-A2 | ALLOSTERIC ADENOSINE RECEPTOR MODULATORS | King Pharmaceuticals Research and Development Inc. (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2004010136-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2004-01-29 | — | — | WO | disclosed |
| WO-2003081202-A2 | BIOCONJUGATE-NANOPARTICLE PROBES | NANOSPHERE, INC. (US) | 2003-10-02 | — | — | WO | disclosed |
| US-20030143598-A1 | Bioconjugate-nanoparticle probes | NANOSPHERE, INC. | 2003-07-31 | — | — | US | disclosed |
| US-20020147190-A1 | Process for preparing 6-aryl-4H-S-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-10-10 | — | — | US | disclosed |
| WO-2002074056-A2 | ALLOSTERIC ADENOSINE RECEPTOR MODULATORS | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT INC. (US) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190233384-A1 | ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF | ELANE, MPO, NISCH | TLR8 515/4885LIPG 2936/4885HTR2A 4814/4885 |
| US-20020147190-A1 | Process for preparing 6-aryl-4H-S-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines | CBR1, HRH1, HRH4 | TLR8 3752/4885LIPG 4809/4885HTR2A 204/4885 |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | MICA, VIP, NPEPPS | TLR8 1676/4885LIPG 3606/4885HTR2A 3769/4885 |
| US-11130741-B2 | Anti-infective heterocyclic compounds and uses thereof | ELANE, MPO, NISCH | TLR8 515/4885LIPG 2936/4885HTR2A 4814/4885 |
| US-20030143598-A1 | Bioconjugate-nanoparticle probes | DNTT, TST, APEX1 | TLR8 3906/4885LIPG 4458/4885HTR2A 4711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.