Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9310915 | 0.86 | AGTR1 (0.33) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9308306 | 0.85 | POLB (0.39) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7312942 | 0.78 | KDM4E (0.62) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9309279 | 0.75 | AGTR1 (0.38) | — | |
| SCHEMBL9310909 | 0.71 | NPC1 (0.32) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL7302852 | 0.70 | KDM4E (0.44) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9663244 | 0.70 | MAPT (0.35) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7302152 | 0.68 | KDM4E (0.46) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8549279 | 0.68 | KDM4E (0.43) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL21810462 | 0.68 | TAS2R14 (0.46) | KDM4ESMN1; SMN2ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |