Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9310915 | 0.86 | AGTR1 (0.33) | NPC1RAB9ASMN1; SMN2NR1H4NFKB1 | |
| SCHEMBL9308306 | 0.85 | POLB (0.39) | NPC1RAB9ASMN1; SMN2TAS2R14NFKB1 | |
| SCHEMBL9309273 | 0.77 | AGTR1 (0.34) | — | |
| SCHEMBL9308311 | 0.71 | KDM4E (0.44) | NPC1RAB9ASMN1; SMN2NFKB1MEN1 | |
| SCHEMBL8544448 | 0.70 | KMT2A (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL901518 | 0.70 | NR1H4 (0.41) | SMN1; SMN2NR1H4RXRARXRBRXRG | |
| SCHEMBL8550098 | 0.69 | MEN1 (0.39) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7314778 | 0.67 | TSHR (0.46) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL21810462 | 0.67 | TAS2R14 (0.46) | SMN1; SMN2TAS2R14ALDH1A1KMT2AFABP4 | |
| SCHEMBL1069725 | 0.66 | FOLH1 (0.51) | RXRARXRBRXRGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |