Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9309023 | 0.92 | ALDH1A1 (0.46) | ALDH1A1KDM4EHSD17B10RXFP1MAPT | |
| SCHEMBL9305414 | 0.77 | ELANE (0.45) | ALDH1A1KDM4ERXFP1MAPTKMT2A | |
| SCHEMBL9305135 | 0.77 | MAPT (0.46) | ALDH1A1KDM4EHSD17B10MAPTKMT2A | |
| SCHEMBL9309039 | 0.74 | AKR1B1 (0.51) | ALDH1A1KDM4EHSD17B10MAPTKMT2A | |
| SCHEMBL2118762 | 0.73 | ALDH1A1 (0.55) | ALDH1A1KDM4EHSD17B10TSHRRXFP1 | |
| SCHEMBL11637562 | 0.73 | AKR1B1 (0.65) | ALDH1A1KDM4EHSD17B10RXFP1MAPT | |
| SCHEMBL9307792 | 0.71 | RAB9A (0.50) | ALDH1A1KDM4EHSD17B10MAPTKMT2A | |
| SCHEMBL13343425 | 0.71 | ALDH1A1 (0.54) | ALDH1A1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL2117475 | 0.69 | ALDH1A1 (0.54) | ALDH1A1KDM4EHSD17B10TSHRRXFP1 | |
| SCHEMBL9306585 | 0.67 | KDM4E (0.44) | ALDH1A1KDM4EHSD17B10MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340808-A | Fused pyridazinoquinazolone derivatives as neurotrophic agents | WARNER LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| WO-1994011373-A1 | PYRIDAZINOQUINAZOLONE DERIVATIVES AS NEUROTROPHIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |