Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9308710 | 0.87 | TRPA1 (0.34) | GAAKDM4EMAPTLMNAL3MBTL1 | |
| Bromide SCHEMBL9309741 | 0.76 | ALDH1A1 (0.31) | ALDH1A1TDP1 | |
| SCHEMBL4961217 | 0.64 | L3MBTL1 (0.81) | GAAKDM4EMAPTLMNAL3MBTL1 | |
| SCHEMBL30055347 | 0.64 | ALDH1A1 (0.49) | GAAKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL2634852 | 0.64 | ALDH1A1 (0.49) | GAAKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL14921128 | 0.64 | L3MBTL1 (0.60) | GAAKDM4EMAPTLMNAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL784570 | 0.63 | L3MBTL1 (0.59) | GAAKDM4EMAPTLMNAL3MBTL1 | |
| SCHEMBL4452273 | 0.62 | ALDH1A1 (0.56) | GAAKDM4EMAPTLMNAL3MBTL1 | |
| SCHEMBL10611673 | 0.62 | MAPK1 (0.56) | GAAKDM4EMAPTLMNAL3MBTL1 | |
| Bromide SCHEMBL9309032 | 0.62 | KDM4E (0.41) | GAAKDM4EMAPTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5321002-A | Herbicidal derivatives of 2-(1-aryl-4-cyano-5-pyrazolylmethyleneiminooxy)alkanoic acids | FMC CORPORATION (US) | 1994-06-14 | — | — | US | disclosed |