Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.56 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.56 |
| ▸ | THRA | P10827 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9304941 | 0.89 | PTPN11 (0.62) | ATMS1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL9307491 | 0.86 | S1PR2 (0.57) | ATMS1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL9306444 | 0.85 | S1PR2 (0.55) | S1PR2S1PR1S1PR3LPAR2THRA | |
| SCHEMBL6597498 | 0.84 | RORC (0.54) | ATMSMN1; SMN2MEN1NPC1TP53 | |
| SCHEMBL5144262 | 0.83 | ATM (0.62) | ATMTHRATHRBSMN1; SMN2GLA | |
| SCHEMBL9398842 | 0.82 | SMN1; SMN2 (0.70) | ATMS1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL18643845 | 0.81 | SMN1; SMN2 (0.60) | ATMS1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL14444189 | 0.80 | SMN1; SMN2 (0.51) | ATMS1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL14444188 | 0.80 | SMN1; SMN2 (0.51) | ATMS1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL11321553 | 0.80 | THRA (0.67) | ATMS1PR2S1PR1S1PR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |