Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.62 |
| ▸ | THRA | P10827 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.56 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.55 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5144262 | 0.94 | ATM (0.62) | PTPN11PTPN1PTPN6THRATHRB | |
| SCHEMBL4321455 | 0.90 | CSNK2A1 (0.63) | PTPN11PTPN1PTPN6ATMLTB4R | |
| SCHEMBL9309743 | 0.89 | ATM (0.56) | PTPN11PTPN1PTPN6THRATHRB | |
| SCHEMBL5093658 | 0.87 | PTPN11 (0.66) | PTPN11PTPN1PTPN6THRATHRB | |
| SCHEMBL5138907 | 0.87 | PTPN11 (0.66) | PTPN11PTPN1PTPN6THRATHRB | |
| SCHEMBL9307491 | 0.86 | S1PR2 (0.57) | PTPN11PTPN1PTPN6THRATHRB | |
| SCHEMBL10899796 | 0.84 | CA2 (0.56) | THRBLTB4RLTB4R2SMN1; SMN2PPARG | |
| SCHEMBL9306902 | 0.83 | PTPN11 (0.62) | PTPN11PTPN1PTPN6THRATHRB | |
| SCHEMBL9398842 | 0.82 | SMN1; SMN2 (0.70) | THRATHRBATMS1PR2S1PR1 | |
| SCHEMBL18682278 | 0.81 | THRA (0.68) | PTPN11THRATHRBPLA2G4BTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |