SCHEMBL9311569

SCHEMBL9311569

Cc1cccc(-c2ccccc2)c1NC#N

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.40
CYP2B6 P20813 1/20 0.40
ALDH1A1 P00352 4/20 0.39
HPGD P15428 3/20 0.39
TSHR P16473 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
ESR2 Q92731 1/20 0.38
S1PR4 O95977 1/20 0.38
NRP1 O14786 1/20 0.37
PDCD1 Q15116 1/20 0.37
CD274 Q9NZQ7 1/20 0.37
SCN8A Q9UQD0 1/20 0.35
NPSR1 Q6W5P4 2/20 0.35
LMNA P02545 1/20 0.35
HTT P42858 1/20 0.35
KDM4E B2RXH2 2/20 0.35
ALOX15 P16050 1/20 0.35
MAOA P21397 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11174526 0.80 TSHR (0.41) CYP2A6ALDH1A1TSHRSMN1; SMN2NPC1
SCHEMBL9537241 0.79 ADORA1 (0.38) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL16351359 0.77 ALDH1A1 (0.47) CYP2A6CYP2B6ALDH1A1HPGDTSHR
SCHEMBL18509790 0.77 ESR2 (0.42) CYP2A6CYP2B6ALDH1A1HPGDTSHR
SCHEMBL9536942 0.76 PTGS2 (0.44) ALDH1A1HPGDSMN1; SMN2RAB9ANPSR1
SCHEMBL28350594 0.74 CXCR2 (0.50) CYP2A6CYP2B6ALDH1A1HPGDTSHR
SCHEMBL728547 0.73 RAPGEF4 (0.40) CYP2A6ALDH1A1TSHRNPC1RAB9A
SCHEMBL27988900 0.72 ALDH1A1 (0.50) CYP2A6CYP2B6ALDH1A1HPGDTSHR
SCHEMBL3376658 0.72 ALDH1A1 (0.49) ALDH1A1HPGDTSHRSMN1; SMN2NPC1
Water SCHEMBL8948779 0.71 ESR2 (0.52) CYP2A6CYP2B6ALDH1A1HPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0536151-B1 ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM BOOTS CO PLC (GB) 1994-09-14 EP disclosed
US-5302720-A Biphenyl-substituted guanidine derivatives useful as hypoglycaemic agents THE BOOTS COMPANY (GB) 1994-04-12 US disclosed
EP-0536151-A1 ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM. BOOTS CO PLC (GB) 1993-04-14 EP disclosed
WO-1992000273-A1 ORTHOSUBSTITUTED BIPHENYL AMIDINE AND BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM THE BOOTS COMPANY PLC (GB) 1992-01-09 WO disclosed