Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 3/20 | 0.44 |
| ▸ | MC5R | P33032 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312223 | 1.00 | LMNA (0.50) | LMNAOPRD1OPRK1ALDH1A1MAPT | |
| SCHEMBL9312229 | 1.00 | LMNA (0.50) | LMNAOPRD1OPRK1ALDH1A1MAPT | |
| SCHEMBL9311168 | 0.86 | OPRD1 (0.52) | OPRD1OPRK1ALDH1A1 | |
| SCHEMBL9876987 | 0.85 | OPRD1 (0.48) | OPRD1OPRK1MC4RMC5ROPRM1 | |
| SCHEMBL9876994 | 0.85 | OPRD1 (0.48) | OPRD1OPRK1MC4RMC5ROPRM1 | |
| SCHEMBL9876991 | 0.85 | OPRD1 (0.48) | OPRD1OPRK1MC4RMC5ROPRM1 | |
| SCHEMBL14282250 | 0.75 | ALDH1A1 (0.48) | LMNAOPRD1OPRK1ALDH1A1HPGD | |
| SCHEMBL9744559 | 0.75 | KMT2A (0.47) | ALDH1A1TSHRHTTSMN1; SMN2MEN1 | |
| SCHEMBL9311700 | 0.75 | KMT2A (0.47) | ALDH1A1TSHRHTTSMN1; SMN2MEN1 | |
| SCHEMBL9311693 | 0.75 | KMT2A (0.47) | ALDH1A1TSHRHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |