Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312492 | 0.85 | LMNA (0.42) | TYRLMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL9312490 | 0.78 | MEN1 (0.45) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL9313037 | 0.77 | LMNA (0.39) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL28875498 | 0.76 | MEN1 (0.58) | TYRMEN1KMT2AALOX5 | |
| SCHEMBL9312569 | 0.76 | LMNA (0.44) | LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL9313101 | 0.76 | TYR (0.56) | TYRMEN1KMT2AALOX5MAPT | |
| SCHEMBL28347944 | 0.74 | TYR (0.49) | TYRMEN1KMT2AALOX5MAPT | |
| SCHEMBL21729219 | 0.72 | IDO1 (0.47) | LMNASMN1; SMN2 | |
| SCHEMBL156238 | 0.71 | TYR (0.60) | TYRMEN1KMT2AALOX5LMNA | |
| SCHEMBL838151 | 0.71 | CA2 (0.56) | KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5366996-A | Administering hydroxamic acids | ELFORD HOWARD L (US) | 1994-11-22 | — | — | US | disclosed |
| US-5183828-A | Ribonucleotide reductase inhibitor and free radical scavenger | RIET BARTHOLOMEUS VAN T (US) | 1993-02-02 | — | — | US | disclosed |
| US-4942253-A | INHIBITORS OF RIBONUCLEOTIDE REDUCTASE, ANTITUMOR AGENTS, LEUKEMIA, FREE RADICAL SCAVENGERS | RIET BARTHOLOMEUS VAN T (US) | 1990-07-17 | — | — | US | disclosed |
| US-4623659-A | RIBONUCLEOTIDE REDUCTASE INHIBITORS | RIET BARTHOLOMEUS VAN T (US) | 1986-11-18 | — | — | US | disclosed |