Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HK2 | P52789 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312587 | 0.84 | LMNA (0.50) | LMNASMN1; SMN2KDM1AALDH1A1HSD17B10 | |
| SCHEMBL9313064 | 0.76 | TYR (0.52) | LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL9312492 | 0.76 | LMNA (0.42) | LMNASMN1; SMN2KDM1AALDH1A1CYP3A4 | |
| SCHEMBL6789908 | 0.74 | CA2 (0.45) | LMNAESR1ADORA3NPY1RPTGS2 | |
| SCHEMBL9313934 | 0.74 | ESR2 (0.37) | LMNAESR1ADORA3NPY1RPTGS2 | |
| SCHEMBL9312490 | 0.72 | MEN1 (0.45) | LMNASMN1; SMN2KDM1AKDM4EALDH1A1 | |
| SCHEMBL9312668 | 0.72 | ESR1 (0.33) | ESR1ADORA3NPY1RPTGS2OPRD1 | |
| SCHEMBL9313037 | 0.72 | LMNA (0.39) | LMNASMN1; SMN2KDM1AALDH1A1 | |
| SCHEMBL5463172 | 0.71 | TAAR1 (0.52) | MTORKDM4EALDH1A1THPOHSD17B10 | |
| SCHEMBL633722 | 0.70 | ESR2 (0.40) | LMNAESR1ADORA3NPY1RPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5366996-A | Administering hydroxamic acids | ELFORD HOWARD L (US) | 1994-11-22 | — | — | US | disclosed |
| US-5183828-A | Ribonucleotide reductase inhibitor and free radical scavenger | RIET BARTHOLOMEUS VAN T (US) | 1993-02-02 | — | — | US | disclosed |
| US-4942253-A | INHIBITORS OF RIBONUCLEOTIDE REDUCTASE, ANTITUMOR AGENTS, LEUKEMIA, FREE RADICAL SCAVENGERS | RIET BARTHOLOMEUS VAN T (US) | 1990-07-17 | — | — | US | disclosed |
| US-4623659-A | RIBONUCLEOTIDE REDUCTASE INHIBITORS | RIET BARTHOLOMEUS VAN T (US) | 1986-11-18 | — | — | US | disclosed |