Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | NEK2 | P51955 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | EP300 | Q09472 | 1/20 | 0.55 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.55 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990307 | 0.85 | CHEK1 (0.73) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL29919884 | 0.85 | CHEK1 (0.73) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL6562728 | 0.77 | HPRT1 (0.46) | MAPTHTTLMNANPSR1SLC6A4 | |
| SCHEMBL30366540 | 0.77 | HPRT1 (0.46) | MAPTHTTLMNANPSR1SLC6A4 | |
| SCHEMBL8720110 | 0.75 | CHEK1 (0.65) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL1755244 | 0.74 | CYP1A2 (0.62) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL29862285 | 0.74 | CYP1A2 (0.62) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL29403281 | 0.74 | NFE2L2 (0.53) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL11895872 | 0.74 | NFE2L2 (0.53) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL11895869 | 0.74 | NFE2L2 (0.53) | CHEK1NEK2LIMK1DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465880-B1 | 5-SULPHANYL-4H-1,2,4-TRIAZOLE DERIVATIVES AND THEIR USE TO TREAT DISORDERS ASSOCIATED WITH SOMATOSTATINE | IPSEN PHARMA (FR) | 2009-08-05 | — | — | EP | disclosed |
| CN-1051702-C | Preparing process of amine derivative and fungusicide containing amine derivative | SCIENT RESEARCH AND PHARMACEUT (JP) | 2000-04-26 | — | — | CN | disclosed |
| US-RE34770-E | 1-benzothiophene derivatives; side effect reduction | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1994-11-01 | — | — | US | disclosed |
| US-5334628-A | Amine derivatives, processes for preparing the same and fungicides containing the same | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1994-08-02 | — | — | US | disclosed |
| US-5200423-A | AMINE DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND FUNGICIDES CONTAINING THE SAME | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1993-04-06 | — | — | US | disclosed |
| US-5106866-A | Skin disorders | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1992-04-21 | — | — | US | disclosed |
| US-5021458-A | Amine derivatives and fungicides containing the same | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0164697-B1 | AMINE DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND FUNGICIDES CONTAINING THE SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 1990-11-07 | — | — | EP | disclosed |
| CN-1007975-B | Process for the preparation of amine derivatives | KAKEN PHARMACEUFICAL CO LTD (JP) | 1990-05-16 | — | — | CN | disclosed |
| CN-1035771-A | Process for the preparation of amine derivatives and fungicides containing amine derivatives | SCIENT RESEARCH AND PHARMACEUT (JP) | 1989-09-27 | — | — | CN | disclosed |
| CN-85104330-A | Process for the preparation of amine derivatives and fungicides containing amine derivatives | — | 1986-12-03 | — | — | CN | disclosed |
| EP-0164697-A2 | Amine derivatives, processes for preparing the same and fungicides containing the same | Kaken Pharmaceutical Co., Ltd. (JP) | 1985-12-18 | — | — | EP | disclosed |