Phenibut

Phenibut

SCHEMBL340838

NCC(CC(=O)O)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GABBR2 O75899 6/20 1.00
GABBR1 Q9UBS5 6/20 1.00
LMNA P02545 2/20 0.70
CYP2C9 P11712 2/20 0.70
CYP2C19 P33261 2/20 0.70
MEN1 O00255 2/20 0.70
KMT2A Q03164 2/20 0.70
CYP3A4 P08684 1/20 0.70
ADORA3 P0DMS8 1/20 0.70
NFKB1 P19838 1/20 0.70
DRD3 P35462 1/20 0.70
BLM P54132 1/20 0.70
CYP1A2 P05177 1/20 0.70
CYP2D6 P10635 1/20 0.70
THRB P10828 1/20 0.70
TSHR P16473 1/20 0.70
MAPT P10636 1/20 0.53
GAA P10253 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenibut SCHEMBL9545047 1.00 GABBR2 (1.00) GABBR2GABBR1LMNACYP2C9CYP2C19
Phenibut SCHEMBL351501 1.00 GABBR2 (1.00) GABBR2GABBR1LMNACYP2C9CYP2C19
Phenibut SCHEMBL22831453 0.98 GABBR2 (0.96) GABBR2GABBR1LMNACYP2C9CYP2C19
Phenibut SCHEMBL3053795 0.98 GABBR2 (0.96) GABBR2GABBR1LMNACYP2C9CYP2C19
Phenibut SCHEMBL27912811 0.96 GABBR2 (0.92) GABBR2GABBR1LMNACYP2C9CYP2C19
Phenibut SCHEMBL28119792 0.94 GABBR2 (0.89) GABBR2GABBR1LMNACYP2C9CYP2C19
SCHEMBL503819 0.87 GABBR2 (0.76) GABBR2GABBR1LMNACYP2C9CYP2C19
SCHEMBL27691658 0.86 GABBR2 (0.75) GABBR2GABBR1LMNACYP2C9CYP2C19
Hydrochloric Acid SCHEMBL7092228 0.85 GABBR2 (0.73) GABBR2GABBR1LMNACYP2C9CYP2C19
SCHEMBL6734410 0.85 GABBR2 (0.73) GABBR2GABBR1LMNACYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1062 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12578348-B2 Blood indicators of Alzheimer's disease THE INSTITUTE FOR ETHNOMEDICINE (US) 2026-03-17 US claimed
US-20260000726-A1 Synergistic Herbal Compositions for Pain Management and Opioid Use Reduction PFOHL JEFFREY L (US) 2026-01-01 US claimed
US-20250382671-A1 METHODS OF DETECTION AND ANALYSIS OF NUCLEIC ACID IN CIRCULATING BODILY FLUIDS Brain Chemistry Labs (US) 2025-12-18 US claimed
US-20250375429-A1 OBLIGATE PAIRING OF ORTHOSTERIC AND NON-ORTHOSTERIC GABA LIGANDS IN PHARMACEUTICAL FORMULATIONS SMARTER NOT HARDER, INC. (US) 2025-12-11 US claimed
EP-4633638-A1 TREATMENT OF PSYCHOLOGICAL FACTORS AFFECTING OTHER MEDICAL CONDITIONS (PFAOMC) Luminous Mind Inc. (US) 2025-10-22 EP claimed
US-20250228772-A1 DRUG DELIVERY SYSTEM COMPRISING A REFLUX INHIBITOR FOR THE APPLICATION TO ESOPHAGEAL MUCOUS MEMBRANES ESOCAP AG (CH) 2025-07-17 US claimed
US-20250186401-A1 COMBINATORIAL ACTIVATION OF GABA(B) AND A2 ADRENERGIC RECEPTORS PROVIDES RELIEF FROM STRESS INDUCED DEPRESSION UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2025-06-12 US claimed
CN-120025976-A Method for differentiating hematopoietic stem/progenitor cells into granulocytes 苏州血霁生物科技有限公司 2025-05-23 CN claimed
US-20250163379-A1 METHOD FOR DIFFERENTIATING HEMATOPOIETIC STEM/PROGENITOR CELLS INTO NK CELLS HEMACELL BIOTECHNOLOGY INC. (CN) 2025-05-22 US claimed
EP-4536194-A1 DRUG DELIVERY SYSTEM COMPRISING A REFLUX INHIBITOR FOR THE APPLICATION TO ESOPHAGEAL MUCOUS MEMBRANES EsoCap AG (CH) 2025-04-16 EP claimed
WO-2004105795-A1 PHARMACEUTICAL COMBINATIONS OF A PROTON PUMP INHIBITOR AND A COMPOUND WHICH MODIFIES GASTROINTESTINAL MOTILITY ALTANA PHARMA AG (DE) 2004-12-09 WO claimed
WO-2004012762-A2 METHOD AND COMPOSITION FOR PROTECTING NEURONAL TISSUE FROM DAMAGE INDUCED BY ELEVATED GLUTAMATE LEVELS YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2004-02-12 WO claimed
EP-0936906-B1 REFLUX INHIBITORS ASTRAZENECA AB (SE) 2003-09-10 EP claimed
US-20030162754-A1 Use of GABA and GABAB agonists TUFTS UNIVERSITY 2003-08-28 US claimed
US-6117908-A Use of GABAB receptor agonists as reflux inhibitors ASTRA AKTIEBOLAG (SE) 2000-09-12 US claimed
WO-1996011680-A2 USE OF GABA AGONISTS IN THE TREATMENT OF EMESIS GLAXO GROUP LIMITED (GB) 1996-04-25 WO claimed
EP-0023192-B1 CYCLOPEPTIDES AND PHARMACEUTICAL PREPARATIONS THEREOF, PROCESS FOR THEIR PREPARATION AND THEIR USE CIBA-GEIGY AG (CH) 1984-03-28 EP claimed
EP-0051278-A1 Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same MERCK & CO. INC. (US) 1982-05-12 EP claimed
US-4328214-A OCTAPEPTIDES, ANTIDIABETICS, TREATING BLOOD LOSSES IN GASTROINTESTINAL TRACT CIBA-GEIGY CORPORATION (US) 1982-05-04 US claimed
US-3947492-A Process for producing β-phenyl-γ-amino butyric acid hydrochloride PEREKALIN VSEVOLOD VASILIEVICH 1976-03-30 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250228772-A1 DRUG DELIVERY SYSTEM COMPRISING A REFLUX INHIBITOR FOR THE APPLICATION TO ESOPHAGEAL MUCOUS MEMBRANES HSPA5, MLNR, HRH2 GABBR2 475/4885GABBR1 790/4885LMNA 1353/4885
US-20260000726-A1 Synergistic Herbal Compositions for Pain Management and Opioid Use Reduction OPRK1, OPRM1, OPRD1 GABBR2 73/4885GABBR1 61/4885LMNA 3204/4885
US-20250186401-A1 COMBINATORIAL ACTIVATION OF GABA(B) AND A2 ADRENERGIC RECEPTORS PROVIDES RELIEF FROM STRESS INDUCED DEPRESSION GABRB2, GABRB1, ADRB2 GABBR2 13/4885GABBR1 19/4885LMNA 2696/4885
US-12578348-B2 Blood indicators of Alzheimer's disease COMT, MAOB, ACHE GABBR2 137/4885GABBR1 94/4885LMNA 1097/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.