Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | RECQL | P46063 | 3/20 | 0.37 |
| ▸ | BLM | P54132 | 3/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932044 | 0.86 | S1PR1 (0.39) | S1PR1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL931075 | 0.79 | SIGMAR1 (0.48) | S1PR1 | |
| SCHEMBL9901142 | 0.76 | HDAC1 (0.43) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL16370572 | 0.76 | ATAD2 (0.44) | S1PR1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL14473305 | 0.74 | ALDH1A1 (0.50) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL14473300 | 0.74 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL466270 | 0.72 | ALDH1A1 (0.63) | MEN1KMT2AKDM4EMAPTTDP1 | |
| SCHEMBL1867023 | 0.71 | MAPT (0.45) | KMT2AMAPTMAPK1TDP1ALDH1A1 | |
| SCHEMBL3782121 | 0.71 | NOTUM (0.62) | KDM4EMAPTRECQLALDH1A1LMNA | |
| SCHEMBL2594028 | 0.71 | CA1 (0.50) | MEN1KMT2AKDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448934-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | AstraZeneca AB (SE) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002405-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |