Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202060 | 0.83 | CA12 (0.40) | ALDH1A1CYP1A2CYP2C19MTNR1APGR | |
| SCHEMBL9315800 | 0.80 | ALDH1A1 (0.43) | MAOAMAOBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL9200232 | 0.80 | MAOB (0.45) | MAOBALDH1A1CYP1A2CYP2C19MTNR1A | |
| SCHEMBL9201848 | 0.80 | CYP2A6 (0.41) | PIM1MAOAALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL9195715 | 0.78 | ACHE (0.55) | MAOBALDH1A1CYP1A2CYP2C19MTNR1A | |
| SCHEMBL9197524 | 0.77 | TSHR (0.39) | ALDH1A1CYP1A2CYP2C19MTNR1ACHRNB2 | |
| SCHEMBL9315026 | 0.77 | ACHE (0.41) | ALDH1A1CYP1A2CYP2C19PARP1MTNR1A | |
| SCHEMBL9315695 | 0.73 | MTNR1A (0.37) | ALDH1A1CYP1A2CYP2C19MTNR1ACHRNB2 | |
| SCHEMBL9316757 | 0.73 | PDE4A (0.38) | ALDH1A1CYP1A2CYP2C19MTNR1APDE4A | |
| SCHEMBL7085848 | 0.73 | PIM1 (0.45) | PIM1PIM2MAOAMAOBADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278166-A | 4-amino-3-heteroaryl butyric acid compounds, compositions, and their use for treating disorders involving a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5214063-A | 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1993-05-25 | — | — | US | disclosed |
| US-5162364-A | Treatment of spastic and senescence disorders | ADIR ET COMPAGNIE (FR) | 1992-11-10 | — | — | US | disclosed |