Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831503 | 0.95 | IDO1 (0.40) | IDO1KCNJ6KCNJ5KCNJ3PTGS1 | |
| SCHEMBL9831600 | 0.91 | NPY5R (0.43) | IDO1PTGS1PTGS2LMNAMAPT | |
| SCHEMBL9832144 | 0.90 | RIPK1 (0.41) | KCNJ6KCNJ5KCNJ3PTGS1PTGS2 | |
| SCHEMBL8111901 | 0.90 | TP53 (0.42) | PTGS1PTGS2MAPTKMT2ATP53 | |
| SCHEMBL9833282 | 0.89 | TP53 (0.39) | PTGS1PTGS2MAPTPOLBMEN1 | |
| SCHEMBL9316263 | 0.88 | RIPK1 (0.41) | KCNJ6KCNJ5KCNJ3LMNAMAPT | |
| SCHEMBL10568020 | 0.88 | POLB (0.42) | KCNJ6KCNJ5KCNJ3LMNAMAPT | |
| SCHEMBL9832440 | 0.88 | TP53 (0.40) | IDO1MAPTPOLBKMT2ATP53 | |
| SCHEMBL9834996 | 0.88 | TP53 (0.38) | PTGS1PTGS2MAPTPOLBALDH1A1 | |
| SCHEMBL9833272 | 0.88 | TP53 (0.38) | KCNJ6KCNJ5KCNJ3PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274443-B1 | HETEROARYL 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-05-29 | — | — | EP | claimed |
| US-5352676-A | Morphalinomethyl-substituted 1-phenyl-indero-[1,2-c]pyrazol-3-yl derivatives of 2-cyano-3-oxo-propanamides useful in the treatment of rheumatoid arthritis | FARMITALIA CARLO ERBA SRL (IT) | 1994-10-04 | — | — | US | disclosed |
| EP-0434807-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | ERBA CARLO SPA (IT) | 1994-06-08 | — | — | EP | disclosed |
| EP-0423269-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | ERBA CARLO SPA (IT) | 1994-01-12 | — | — | EP | disclosed |
| US-5260328-A | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis | FARMITALIA CARLO ERBA SRL (IT) | 1993-11-09 | — | — | US | disclosed |
| US-5196445-A | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | FARMITALIA CARLO ERBA SRL (IT) | 1993-03-23 | — | — | US | disclosed |
| EP-0274443-B1 | HETEROARYL 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-05-29 | — | — | EP | disclosed |
| WO-1991001309-A1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-02-07 | — | — | WO | disclosed |
| US-4816467-A | BACTERICIDES, VIRICIDES | FARMITALIA CARLO ERBA S.R.L (IT) | 1989-03-28 | — | — | US | disclosed |
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | disclosed |