1-Naphthol

1-Naphthol

SCHEMBL9316261

Nc1ccc(O)cc1.Oc1cccc2ccccc12

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.68
PLAU P00749 1/20 0.60
CTDSP1 Q9GZU7 1/20 0.60
ALDH1A1 P00352 2/20 0.52
CYP3A4 P08684 2/20 0.52
HSD17B10 Q99714 2/20 0.52
CA3 P07451 1/20 0.52
THRB P10828 1/20 0.52
ALOX15 P16050 1/20 0.52
CA6 P23280 1/20 0.52
CASP1 P29466 1/20 0.52
HIF1A Q16665 1/20 0.52
CA14 Q9ULX7 1/20 0.52
ESR1 P03372 2/20 0.52
ESR2 Q92731 2/20 0.52
HSD17B1 P14061 1/20 0.52
HSD17B2 P37059 1/20 0.52
NQO2 P16083 1/20 0.45
HPGD P15428 1/20 0.45
TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1-Naphthol SCHEMBL8410220 0.94 CYP1A2 (0.77) CYP1A2PLAUCTDSP1ALDH1A1CYP3A4
1-Naphthol SCHEMBL27861388 0.88 CYP1A2 (0.74) CYP1A2PLAUCTDSP1ALDH1A1CYP3A4
4-Aminophenol SCHEMBL5573958 0.85 PLAU (0.85) CYP1A2PLAUCTDSP1ALDH1A1CYP3A4
1-Naphthol SCHEMBL28034918 0.85 CYP1A2 (0.63) CYP1A2PLAUCTDSP1ALDH1A1CYP3A4
1-Naphthol SCHEMBL29959385 0.83 CYP1A2 (0.81) CYP1A2PLAUCTDSP1ALDH1A1HSD17B10
1-Naphthol SCHEMBL94756 0.83 CYP1A2 (0.81) CYP1A2PLAUCTDSP1ALDH1A1HSD17B10
1-Naphthol SCHEMBL28127258 0.83 CYP1A2 (0.81) CYP1A2PLAUCTDSP1ALDH1A1HSD17B10
1-Naphthol SCHEMBL28448239 0.83 CYP1A2 (0.81) CYP1A2PLAUCTDSP1ALDH1A1HSD17B10
1-Naphthol SCHEMBL29767730 0.82 CYP1A2 (1.00) CYP1A2PLAUCTDSP1ALDH1A1CYP3A4
1-Naphthol SCHEMBL273260 0.82 CYP1A2 (1.00) CYP1A2PLAUCTDSP1ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104428340-B Phenol resin composition 日立化成株式会社 2019-01-22 CN disclosed
CN-106265133-A Foam Oxidative Hair Colorant Composition 宝洁公司 2017-01-04 CN disclosed
US-5344463-A OXIDATION CLAIROL, INC. (US) 1994-09-06 US disclosed