SCHEMBL9316404

SCHEMBL9316404

N#Cc1ccc(C(F)(F)F)cc1Sc1ccccc1N.Nc1ccccc1S

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
CYP1A2 P05177 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
MAPT P10636 2/20 0.52
LMNA P02545 1/20 0.52
SLC6A2 P23975 3/20 0.43
SLC6A4 P31645 3/20 0.43
SLC6A3 Q01959 1/20 0.43
AR P10275 5/20 0.40
PGR P06401 1/20 0.40
PDE7A Q13946 1/20 0.38
MAP2K2 P36507 1/20 0.37
MAP2K1 Q02750 1/20 0.37
TAS2R14 Q9NYV8 1/20 0.37
KDM4E B2RXH2 2/20 0.36
POLB P06746 1/20 0.36
TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8881283 0.93 CYP1A2 (0.64) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL8880802 0.80 CYP1A2 (0.64) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL8113801 0.75 MAOA (0.51) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL9315173 0.74 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL1772241 0.74 CYP1A2 (1.00) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL463600 0.70 AR (0.47) ALDH1A1MAPTLMNAARTAS2R14
SCHEMBL9132754 0.70 CYP1A2 (0.62) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL17782865 0.69 AR (0.49) ARTAS2R14
SCHEMBL24439575 0.68 MAPT (0.53) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL7113444 0.68 AR (0.47) SLC6A2SLC6A4ARTAS2R14CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0583288-A1 ANTIVIZAL DIBENZOTHIAZEPINONE DERIVATIVES THE WELLCOME FOUNDATION LIMITED (GB) 1994-02-23 EP disclosed
WO-1992019277-A1 ANTIVIRAL DIBENZOTHIAZEPINONE DERIVATIVES THE WELLCOME FOUNDATION LIMITED (GB) 1992-11-12 WO disclosed