Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2040302 | 0.78 | MAPT (0.37) | LMNAMAPTKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL657923 | 0.74 | MAPT (0.46) | LMNAMAPTKDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL17925583 | 0.74 | MAPT (0.36) | LMNAMAPTKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL563397 | 0.73 | F10 (0.43) | LMNAMAPTKDM4ERAB9AL3MBTL1 | |
| SCHEMBL20475329 | 0.72 | MAPT (0.41) | LMNAMAPTKDM4EFBP1ALDH1A1 | |
| SCHEMBL4755117 | 0.71 | NPC1 (0.41) | LMNAMAPTKDM4ERAB9AL3MBTL1 | |
| SCHEMBL16879221 | 0.71 | MAPT (0.39) | LMNAMAPTKDM4EFBP1L3MBTL1 | |
| SCHEMBL9294262 | 0.71 | F2 (0.50) | LMNAMAPTKDM4EALDH1A1F2 | |
| SCHEMBL15548874 | 0.71 | MAPT (0.40) | LMNAMAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL28088708 | 0.71 | MAPT (0.39) | LMNAMAPTKDM4EFBP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278166-A | 4-amino-3-heteroaryl butyric acid compounds, compositions, and their use for treating disorders involving a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5214063-A | 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1993-05-25 | — | — | US | disclosed |
| US-5162364-A | Treatment of spastic and senescence disorders | ADIR ET COMPAGNIE (FR) | 1992-11-10 | — | — | US | disclosed |