⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263456 | 0.84 | TDP1 (0.39) | — | |
| SCHEMBL980928 | 0.82 | TDP1 (0.37) | — | |
| SCHEMBL6576818 | 0.82 | GFER (0.40) | — | |
| SCHEMBL28163490 | 0.80 | THRA (0.40) | — | |
| SCHEMBL7489223 | 0.80 | THRA (0.40) | — | |
| SCHEMBL2281085 | 0.78 | TDP1 (0.71) | — | |
| SCHEMBL11803736 | 0.77 | MAOA (0.40) | — | |
| SCHEMBL242102 | 0.77 | — | — | |
| Water SCHEMBL11482042 | 0.74 | TDP1 (0.57) | — | |
| SCHEMBL11690401 | 0.74 | SIGMAR1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 198 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322816-A1 | PYRAZOLE BORONIC ACID COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USES THEREOF | BEIJING SONGRUN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-10-12 | — | — | US | claimed |
| CN-114075227-B | Pyrazole boric acid compound, pharmaceutical composition containing pyrazole boric acid compound and application of pyrazole boric acid compound and pharmaceutical composition | 北京嵩润医药科技有限责任公司 | 2023-07-04 | — | — | CN | claimed |
| EP-4201941-A1 | PYRAZOLE BORONIC ACID COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USES THEREOF | Beijing Songrun Pharmaceutical Technology Co., Ltd. (CN) | 2023-06-28 | — | — | EP | claimed |
| CN-114075227-A | Pyrazole boronic acid compounds, pharmaceutical compositions comprising the same and uses thereof | 北京大学 | 2022-02-22 | — | — | CN | claimed |
| US-11150555-B2 | Photoacid generator and chemically amplified positive-type photoresist composition for thick film comprising the same | LG CHEM, LTD. (KR) | 2021-10-19 | — | — | US | claimed |
| US-20200033724-A1 | PHOTOACID GENERATOR AND CHEMICALLY AMPLIFIED POSITIVE-TYPE PHOTORESIST COMPOSITION FOR THICK FILM COMPRISING THE SAME | LG CHEM, LTD. (KR) | 2020-01-30 | — | — | US | claimed |
| US-8546441-B2 | PDK-1/AKT signaling inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-10-01 | — | — | US | claimed |
| US-8541460-B2 | Phosphoinositide-dependent kinase-1 (PDK-1) inhibitors; for the treatment and prevention of cancer in humans; 4-[5-(2-Phenanthracenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenecarboxamide | THE OHIO STATE UNIVERSITY (US) | 2013-09-24 | — | — | US | claimed |
| EP-1696907-B1 | PDK-1/AKT SIGNALING INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2013-04-17 | — | — | EP | claimed |
| US-8080574-B2 | PDK-1/Akt signaling inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-12-20 | — | — | US | claimed |
| EP-1648886-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-04-26 | — | — | EP | claimed |
| US-20060079566-A1 | PDK-1/Akt signaling inhibitors | THE NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-04-13 | — | — | US | claimed |
| US-7026346-B2 | Compounds and methods for inducing apoptosis in proliferating cells | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2006-04-11 | — | — | US | claimed |
| EP-1499597-A4 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | UNIV OHIO STATE RES FOUND (US) | 2006-01-25 | — | — | EP | claimed |
| WO-2005044130-A9 | PDK-1/AKT SIGNALING INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2005-09-15 | — | — | WO | claimed |
| WO-2005044130-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-05-19 | — | — | WO | claimed |
| WO-2005014589-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (DE) | 2005-02-17 | — | — | WO | claimed |
| EP-1499597-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-01-26 | — | — | EP | claimed |
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | NIH - DEITR | 2003-12-25 | — | — | US | claimed |
| WO-2003086287-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2003-10-23 | — | — | WO | claimed |