Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.31 |
| ▸ | HRH1 | P35367 | 2/20 | 0.30 |
| ▸ | ESR1 | P03372 | 2/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.30 |
| ▸ | TACR2 | P21452 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SHBG | P04278 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28163490 | 0.98 | THRA (0.40) | TDP1THRATHRBMAOASIGMAR1 | |
| SCHEMBL7489223 | 0.98 | THRA (0.40) | TDP1THRATHRBMAOASIGMAR1 | |
| SCHEMBL263456 | 0.93 | TDP1 (0.39) | TDP1THRATHRBMAOASIGMAR1 | |
| SCHEMBL11803736 | 0.87 | MAOA (0.40) | MAOAMAOBSIGMAR1HRH1ESR1 | |
| SCHEMBL11690401 | 0.85 | SIGMAR1 (0.41) | MAOAMAOBSIGMAR1HRH1ESR1 | |
| SCHEMBL931699 | 0.82 | — | — | |
| SCHEMBL2177163 | 0.82 | THRA (0.47) | TDP1THRATHRBMAOAMAOB | |
| SCHEMBL9673266 | 0.79 | THRA (0.50) | TDP1THRATHRBMAOBSIGMAR1 | |
| SCHEMBL9673289 | 0.79 | THRA (0.50) | TDP1THRATHRBMAOBSIGMAR1 | |
| SCHEMBL9670792 | 0.79 | THRA (0.50) | TDP1THRATHRBMAOBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104721173-B | A kind of bag bromine butylphenyl phthaleine PLGA nano particles and preparation method thereof | 郑州大学 | 2017-08-25 | — | — | CN | claimed |
| US-8546441-B2 | PDK-1/AKT signaling inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-10-01 | — | — | US | claimed |
| US-8541460-B2 | Phosphoinositide-dependent kinase-1 (PDK-1) inhibitors; for the treatment and prevention of cancer in humans; 4-[5-(2-Phenanthracenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenecarboxamide | THE OHIO STATE UNIVERSITY (US) | 2013-09-24 | — | — | US | claimed |
| EP-1696907-B1 | PDK-1/AKT SIGNALING INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2013-04-17 | — | — | EP | claimed |
| US-8080574-B2 | PDK-1/Akt signaling inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-12-20 | — | — | US | claimed |
| JP-4745971-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| US-20110015242-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-01-20 | — | — | US | claimed |
| CN-1889949-B | PDK-1/Akt signaling inhibitors | UNIV OHIO STATE RES FOUND | 2010-06-16 | — | — | CN | claimed |
| US-20090281328-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-11-12 | — | — | US | claimed |
| US-20080146815-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2008-06-19 | — | — | US | claimed |
| EP-1696907-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2006-09-06 | — | — | EP | claimed |
| US-20060142368-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MRDC | 2006-06-29 | — | — | US | claimed |
| US-20060079566-A1 | PDK-1/Akt signaling inhibitors | THE NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-04-13 | — | — | US | claimed |
| US-7026346-B2 | Compounds and methods for inducing apoptosis in proliferating cells | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2006-04-11 | — | — | US | claimed |
| EP-1499597-A4 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | UNIV OHIO STATE RES FOUND (US) | 2006-01-25 | — | — | EP | claimed |
| WO-2005044130-A9 | PDK-1/AKT SIGNALING INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2005-09-15 | — | — | WO | claimed |
| WO-2005044130-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-05-19 | — | — | WO | claimed |
| EP-1499597-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-01-26 | — | — | EP | claimed |
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | NIH - DEITR | 2003-12-25 | — | — | US | claimed |
| WO-2003086287-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2003-10-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015242-A1 | PDK-1/AKT SIGNALING INHIBITORS | PDPK1, TNNI3K, MAP3K1 | TDP1 951/4885THRA 3445/4885THRB 3341/4885 |
| US-20060079566-A1 | PDK-1/Akt signaling inhibitors | PDPK1, PDXK, PDK3 | TDP1 1106/4885THRA 2794/4885THRB 2610/4885 |
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MCL1, BRDT, BAD | TDP1 3959/4885THRA 3882/4885THRB 3241/4885 |
| US-20090281328-A1 | PDK-1/AKT SIGNALING INHIBITORS | PDPK1, PDXK, PI4KA | TDP1 1031/4885THRA 2645/4885THRB 2483/4885 |
| US-20080146815-A1 | PDK-1/AKT SIGNALING INHIBITORS | PDPK1, PDXK, PI4KA | TDP1 1026/4885THRA 2651/4885THRB 2495/4885 |
| US-20060142368-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MCL1, BRDT, BAD | TDP1 4160/4885THRA 3759/4885THRB 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.