SCHEMBL931734

SCHEMBL931734

c1nc2cc(N(c3ccc4scnc4c3)c3ccc4scnc4c3)ccc2s1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.48
HSD17B10 Q99714 1/20 0.48
HSD11B1 P28845 1/20 0.39
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
HKDC1 Q2TB90 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
TRPM5 Q9NZQ8 1/20 0.36
NAMPT P43490 1/20 0.36
MAPK1 P28482 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
DYRK1A Q13627 1/20 0.36
CRBN Q96SW2 2/20 0.35
RIPK2 O43353 4/20 0.34
RIPK3 Q9Y572 2/20 0.34
KDR P35968 2/20 0.34
TGFBR1 P36897 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6758771 0.84 APP (0.48) ALDH1A1HSD17B10HSD11B1KDM4ENPC1
SCHEMBL30209107 0.84 APP (0.48) ALDH1A1HSD17B10HSD11B1KDM4ENPC1
SCHEMBL11865558 0.80 TERT (0.53) ALDH1A1HSD17B10KDM4ENPC1RAB9A
SCHEMBL28048502 0.76 ALDH1A1 (0.54) ALDH1A1HSD17B10HSD11B1KDM4ENPC1
SCHEMBL1848731 0.74 ALDH1A1 (0.45) ALDH1A1HSD17B10MAPK1SMN1; SMN2DYRK1A
SCHEMBL858270 0.72 ALDH1A1 (0.50) ALDH1A1HSD17B10HSD11B1KDM4ENPC1
SCHEMBL2089681 0.72 ALDH1A1 (0.50) ALDH1A1HSD17B10HSD11B1KDM4ENPC1
SCHEMBL927314 0.72 ALDH1A1 (0.50) ALDH1A1HSD17B10HSD11B1KDM4ENPC1
SCHEMBL15810376 0.72 ALDH1A1 (0.50) ALDH1A1HSD17B10HSD11B1KDM4ENPC1
SCHEMBL928156 0.72 ALDH1A1 (0.50) ALDH1A1HSD17B10HSD11B1KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10707426-B2 Liquid crystal photoalignment materials LOMOX LIMITED (GB) 2020-07-07 US disclosed
US-10707426-B2 Liquid crystal photoalignment materials LOMOX LIMITED (GB) 2020-07-07 US disclosed
US-20170084846-A1 Liquid Crystal Photoalignment Materials LOMOX LTD (GB) 2017-03-23 US disclosed
US-20170084846-A1 Liquid Crystal Photoalignment Materials LOMOX LTD (GB) 2017-03-23 US disclosed
US-20170084846-A1 Liquid Crystal Photoalignment Materials LOMOX LTD (GB) 2017-03-23 US disclosed
US-9508942-B2 Liquid crystal photoalignment materials LOMOX LIMITED 2016-11-29 US disclosed
US-9508942-B2 Liquid crystal photoalignment materials LOMOX LIMITED 2016-11-29 US disclosed
US-9508942-B2 Liquid crystal photoalignment materials LOMOX LIMITED 2016-11-29 US disclosed
EP-2361444-B1 CHARGE TRANSPORTING LIQUID CRYSTAL PHOTOALIGNMENT MATERIAL AND METHOD OF FORMING SAID MATERIAL LOMOX LTD (GB) 2016-01-27 EP disclosed
EP-2361444-A1 MATERIALS Lomox Limited (GB) 2011-08-31 EP disclosed
US-20110020566-A1 Materials LOMOX LIMITED (GB) 2011-01-27 US disclosed
US-20110020566-A1 Materials LOMOX LIMITED (GB) 2011-01-27 US disclosed
US-20110020566-A1 Materials LOMOX LIMITED (GB) 2011-01-27 US disclosed
WO-2009103952-A1 MATERIALS LOMOX LIMITED (GB) 2009-08-27 WO disclosed
WO-2009103952-A1 MATERIALS LOMOX LIMITED (GB) 2009-08-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110020566-A1 Materials VIM, EPCAM, S100A4 ALDH1A1 1858/4885HSD17B10 4484/4885HSD11B1 4774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.