SCHEMBL858270

SCHEMBL858270

Brc1ccc2scnc2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
HSD17B10 Q99714 1/20 0.50
EGFR P00533 1/20 0.46
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD11B1 P28845 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
HTT P42858 1/20 0.39
KDM4E B2RXH2 1/20 0.39
HKDC1 Q2TB90 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
PTK6 Q13882 2/20 0.39
RIPK2 O43353 3/20 0.38
RIPK3 Q9Y572 3/20 0.38
TRPM5 Q9NZQ8 1/20 0.37
NAMPT P43490 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29457651 1.00 ALDH1A1 (0.50) ALDH1A1HSD17B10EGFRNPC1RAB9A
SCHEMBL9143839 0.85 RAB9A (0.44) ALDH1A1HSD17B10EGFRNPC1RAB9A
SCHEMBL11213454 0.85 RIPK3 (0.38) ALDH1A1HSD17B10EGFRNPC1RAB9A
SCHEMBL14127237 0.83 NPC1 (0.54) ALDH1A1HSD17B10EGFRNPC1RAB9A
SCHEMBL10543 0.83 NPC1 (0.54) ALDH1A1HSD17B10EGFRNPC1RAB9A
SCHEMBL9300561 0.81 NPC1 (0.44) ALDH1A1HSD17B10EGFRNPC1RAB9A
Hydrazine SCHEMBL27534766 0.79 NPC1 (0.51) ALDH1A1HSD17B10EGFRNPC1RAB9A
SCHEMBL28048502 0.77 ALDH1A1 (0.54) ALDH1A1HSD17B10EGFRNPC1RAB9A
SCHEMBL31514631 0.76 EGFR (0.69) EGFRRIPK2RIPK3RIPK1
SCHEMBL9676880 0.75 ALDH1A1 (0.47) ALDH1A1HSD17B10EGFRNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120004820-A CO utilization2Preparation of benzothiazoles method for preparing compounds 内蒙古工业大学 2025-05-16 CN claimed
CN-117945995-A Alkylated nitrogen-containing heterocyclic compound and preparation method and application thereof 中国科学院青海盐湖研究所 2024-04-30 CN claimed
CN-115433072-B Method for preparing aryl ketone by photocatalytic oxidation 浙江工业大学 2023-08-08 CN claimed
CN-115504942-A Synthesis method of alkyl or acyl substituted benzothiazole derivative 汕头大学 2022-12-23 CN claimed
CN-115433072-A Method for preparing aryl ketone by photocatalytic oxidation 浙江工业大学 2022-12-06 CN claimed
CN-113045993-A Polishing solution for processing ultra-smooth low-damage bearing steel surface and application thereof 西南交通大学 2021-06-29 CN claimed
CN-106432132-A Preparation method of 2-arylbenzothiazole compound 西北师范大学 2017-02-22 CN claimed
CN-102408394-A 2-ethylthio-5-bromobenzothiazole and preparation method and application thereof UNIV ZHEJIANG 2012-04-11 CN claimed
CN-102010385-A Preparation method of 2-methylthio-5-benzothiazole UNIV ZHEJIANG 2011-04-13 CN claimed
EP-0271260-B1 Supersensitization of silver halide emulsions MINNESOTA MINING & MFG (US) 1995-01-04 EP claimed
US-4891305-A LASERS RICOH CO., LTD. (JP) 1990-01-02 US claimed
US-4889796-A CONTAINING BENZOXAZOLE COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1989-12-26 US claimed
US-4873184-A ADDITION OF A METAL COMPLEXING AGENT TO THE EMULSION; HIGH SPEED MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-10-10 US claimed
EP-0271260-A2 Supersensitization of silver halide emulsions MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1988-06-15 EP claimed
US-4102688-A CONTAINING PYRAZOLO(3,4-B)PYRIDINE/3,6-DIONE MOIETY FUJI PHOTO FILM CO., LTD. (JP) 1978-07-25 US claimed
US-3970461-A Fogged, direct-positive silver halide emulsion containing carbocyanine dye having indolenine nucleus FUJI PHOTO FILM CO., LTD. (JA) 1976-07-20 US claimed
US-20260078117-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS INC (US) 2026-03-19 US disclosed
US-12570621-B2 Short-acting 3,4-methylenedioxymethamphetamine (MDMA) analogs incorporating benzothiazole APOAPSIS HOLDINGS, LLC (US) 2026-03-10 US disclosed
US-3936308-A Photographic emulsions containing methine dyes having a 1H-imidazo[4,5-b]pyrazine nucleus EASTMAN KODAK COMPANY (US) 1976-02-03 US disclosed
US-3935010-A IMIDAZOQUINOXALINE DESENSITIZER EASTMAN KODAK COMPANY (US) 1976-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570621-B2 Short-acting 3,4-methylenedioxymethamphetamine (MDMA) analogs incorporating benzothiazole SLC6A3, SLC6A2, HTR2C ALDH1A1 1951/4885HSD17B10 1783/4885EGFR 1574/4885
US-20260078117-A1 COMPOUNDS AND METHODS OF USE NR3C2, ADRA1A, CNR1 ALDH1A1 100/4885HSD17B10 410/4885EGFR 383/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.