SCHEMBL931853

SCHEMBL931853

COc1[c]ccc(CC(C)C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 6/20 0.39
ALOX12 P18054 6/20 0.39
FOS P01100 2/20 0.39
TTR P02766 2/20 0.39
JUN P05412 2/20 0.39
NR3C1 P04150 2/20 0.39
HSD17B1 P14061 2/20 0.39
HSD17B2 P37059 2/20 0.39
GABRA1 P14867 1/20 0.38
GABRB2 P47870 1/20 0.38
TAAR1 Q96RJ0 2/20 0.36
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
KDM4E B2RXH2 2/20 0.32
MEN1 O00255 2/20 0.32
ALDH1A1 P00352 2/20 0.32
ESR1 P03372 2/20 0.32
TP53 P04637 2/20 0.32
CYP3A4 P08684 2/20 0.32
HPGD P15428 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27552892 0.98 ALOX15 (0.38) ALOX15ALOX12FOSTTRJUN
SCHEMBL458330 0.79 PTGS2 (0.42) TP53CYP1A2PTGS2TRPA1
SCHEMBL5871513 0.77 PTPRB (0.43) ALOX15ALOX12ALDH1A1ESR1CYP3A4
SCHEMBL3367670 0.77 LOXL2 (0.43) TAAR1MAOBKDM4EMAPK1HTR2A
SCHEMBL359220 0.77 MAPT (0.38) ALOX15ALOX12TTRRECQLHSD17B10
SCHEMBL28021341 0.76 GABRA1 (0.34) ALOX15ALOX12FOSTTRJUN
SCHEMBL15067851 0.76 GABRA1 (0.42) ALOX15ALOX12FOSTTRJUN
SCHEMBL1171484 0.76 CNR1 (0.37) GABRA1GABRB2TAAR1KDM4EALDH1A1
SCHEMBL7469143 0.75 GABRA1 (0.41) ALOX15ALOX12FOSTTRJUN
SCHEMBL677764 0.75 GABRA1 (0.41) ALOX15ALOX12FOSTTRJUN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011005295-A1 MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2011-01-13 WO claimed
WO-2011005295-A1 MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2011-01-13 WO disclosed