Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12433181 | 0.87 | SLC6A3 (0.51) | KDM4ESLC6A4SLC6A3NPC1RAB9A | |
| SCHEMBL9318354 | 0.87 | KDM4E (0.45) | KDM4EPOLBTP53NPC1RAB9A | |
| SCHEMBL7302152 | 0.86 | KDM4E (0.46) | KDM4EPOLBSLC6A4SLC6A3TP53 | |
| SCHEMBL8544320 | 0.86 | KDM4E (0.63) | KDM4EPOLBTP53NPC1RAB9A | |
| SCHEMBL9320103 | 0.83 | SLC6A3 (0.43) | KDM4ESLC6A4SLC6A3NPC1RAB9A | |
| SCHEMBL9318636 | 0.82 | SLC6A3 (0.47) | KDM4EPOLBSLC6A4SLC6A3TP53 | |
| SCHEMBL9434971 | 0.80 | KDM4E (0.47) | KDM4EPOLBTP53NPC1RAB9A | |
| SCHEMBL7302158 | 0.78 | SLC6A3 (0.46) | KDM4EPOLBSLC6A4SLC6A3TP53 | |
| SCHEMBL9309848 | 0.75 | ALOX5 (0.53) | KDM4EPOLBNPC1RAB9ARXFP1 | |
| SCHEMBL9571330 | 0.75 | CYP4F2 (0.53) | KDM4EMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5317023-A | 2-Phenyl-(imidazo(4,5-b)pyridyl-methyl-) derivatives; hypertensive agents; cognition activators | GLAXO GROUP LIMITED (GB) | 1994-05-31 | — | — | US | disclosed |
| WO-1992020679-A1 | BENZOFURAN DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514197-A1 | Anti-hypertensive benzofuran derivatives substituted by N-imidazolyl-methyl groups which are condensed with optionally nitrogen containing, six-membered rings | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |