Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.53 |
| ▸ | ASPH | Q12797 | 10/20 | 0.53 |
| ▸ | KDM8 | Q8N371 | 9/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | RIOX2 | Q8IUF8 | 7/20 | 0.48 |
| ▸ | DDT | P30046 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10467645 | 0.83 | MAPK1 (0.52) | KDM4EMAPK1L3MBTL1GABRPGABRD | |
| SCHEMBL31318735 | 0.83 | KDM4E (0.50) | KDM4EASPHKDM8MAPK1L3MBTL1 | |
| SCHEMBL1171098 | 0.82 | KDM4E (0.67) | KDM4EASPHKDM8RIOX2DDT | |
| SCHEMBL28985760 | 0.81 | NNMT (0.50) | KDM4EMAPK1L3MBTL1GABRPGABRD | |
| SCHEMBL30703822 | 0.78 | ASPH (0.45) | KDM4EASPHKDM8MAPK1L3MBTL1 | |
| SCHEMBL9318874 | 0.76 | KDM4E (0.55) | KDM4EASPHKDM8MAPK1L3MBTL1 | |
| SCHEMBL9568767 | 0.76 | KDM4E (0.50) | KDM4EASPHKDM8MAPK1L3MBTL1 | |
| SCHEMBL829544 | 0.76 | CA12 (0.47) | KDM4EL3MBTL1 | |
| SCHEMBL337450 | 0.76 | CA12 (0.47) | KDM4EL3MBTL1 | |
| SCHEMBL10616295 | 0.76 | CA12 (0.47) | KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281943-B1 | Substituted pyridine-2,4-carboxylic acid derivatives, process for their preparation, their use as well as medicaments based on these compounds | HOECHST AG (DE) | 1994-01-12 | — | — | EP | claimed |