Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764313 | 0.84 | PTGS2 (0.43) | ALDH1A1L3MBTL1KDM4ETDP1MAPK14 | |
| SCHEMBL9319453 | 0.84 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1KDM4ETDP1MAPK14 | |
| SCHEMBL9320007 | 0.82 | GCGR (0.43) | ALDH1A1L3MBTL1KDM4ETDP1MAPK14 | |
| SCHEMBL9764095 | 0.80 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1KDM4ETDP1PTGS2 | |
| SCHEMBL9320917 | 0.77 | AR (0.50) | AR | |
| SCHEMBL9695099 | 0.73 | PTGS2 (0.39) | ALDH1A1PTGS2PTGS1AR | |
| SCHEMBL9024278 | 0.72 | PTGS2 (0.38) | ALDH1A1MAPK14PTGS2PTGS1HMGCR | |
| SCHEMBL8805119 | 0.72 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1KDM4ETDP1GCGR | |
| SCHEMBL9321090 | 0.71 | GCGR (0.40) | ALDH1A1L3MBTL1KDM4ETDP1MAPK14 | |
| SCHEMBL9664017 | 0.71 | GCGR (0.40) | ALDH1A1L3MBTL1KDM4ETDP1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373423-B1 | Substituted 2-pyridones and pyride-2-thiones, process for their preparation and their use in medicine | BAYER AG (DE) | 1994-01-12 | — | — | EP | disclosed |
| US-5164506-A | Substituted 2-pyridones and pyrid-2-thiones compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1992-11-17 | — | — | US | disclosed |
| US-5032602-A | Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and pyrid-2-thiones | BAYER AKTIENGESELLSCHAFT (DE) | 1991-07-16 | — | — | US | disclosed |