Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5308775 | 0.81 | ALDH1A1 (0.55) | POLBTSHRNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12085953 | 0.80 | MEN1 (0.53) | TP53TDP1KMT2AMEN1CYP2C19 | |
| SCHEMBL11755096 | 0.80 | PTGS2 (0.52) | POLBTSHRNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5263281 | 0.79 | PGR (0.50) | POLBTSHRNPSR1TDP1ALDH1A1 | |
| SCHEMBL8070199 | 0.78 | SMN1; SMN2 (0.53) | POLBTSHRNPSR1HTTTP53 | |
| SCHEMBL6685738 | 0.78 | ALDH1A1 (0.41) | POLBTSHRNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1061987 | 0.77 | PGR (0.60) | POLBNPSR1TDP1ALDH1A1MAPT | |
| SCHEMBL11748084 | 0.76 | POLB (0.52) | POLBTSHRNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6305077 | 0.76 | ALDH1A1 (0.59) | POLBTSHRNPSR1HTTTP53 | |
| SCHEMBL6232603 | 0.75 | ALDH1A1 (0.43) | POLBTSHRNPSR1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286728-A | Amino-substituted piperazine derivatives | CIBA-GEIGY CORPORATION (US) | 1994-02-15 | — | — | US | disclosed |
| EP-0524146-A1 | Aminosubstituted Piperazinederivatives | CIBA-GEIGY AG (CH) | 1993-01-20 | — | — | EP | disclosed |