Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932971 | 0.88 | MCOLN3 (0.58) | SMN1; SMN2MCOLN3TSHRLMNAMEN1 | |
| SCHEMBL933278 | 0.82 | KMT2A (0.54) | SMN1; SMN2MCOLN3TSHRLMNAMEN1 | |
| SCHEMBL932990 | 0.82 | PKM (0.62) | SMN1; SMN2MCOLN3TSHRLMNAMEN1 | |
| SCHEMBL932415 | 0.79 | LMNA (0.53) | SMN1; SMN2MCOLN3TSHRLMNAMEN1 | |
| SCHEMBL932174 | 0.78 | MCOLN3 (0.50) | SMN1; SMN2MCOLN3TSHRLMNAMEN1 | |
| SCHEMBL932192 | 0.77 | PKM (0.52) | SMN1; SMN2MCOLN3TSHRLMNAMEN1 | |
| SCHEMBL932636 | 0.76 | ALDH1A1 (0.50) | SMN1; SMN2LMNAMEN1KMT2APKM | |
| SCHEMBL931956 | 0.76 | MEN1 (0.53) | SMN1; SMN2MCOLN3TSHRLMNAMEN1 | |
| SCHEMBL932255 | 0.74 | MCOLN3 (0.59) | SMN1; SMN2MCOLN3TSHRLMNAMEN1 | |
| SCHEMBL931510 | 0.74 | PKM (0.59) | TSHRLMNAMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448581-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002816-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | WO | disclosed |