Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931510 | 0.91 | PKM (0.59) | ALDH1A1LMNAKMT2AMEN1PKM | |
| SCHEMBL932971 | 0.87 | MCOLN3 (0.58) | ALDH1A1LMNAKMT2AMEN1PKM | |
| SCHEMBL932795 | 0.87 | LMNA (0.42) | LMNAPOLBKMT2AMEN1PKM | |
| SCHEMBL932329 | 0.79 | GBA1 (0.49) | ALDH1A1PKM | |
| SCHEMBL932990 | 0.79 | PKM (0.62) | ALDH1A1LMNAKMT2AMEN1PKM | |
| SCHEMBL933278 | 0.79 | KMT2A (0.54) | ALDH1A1LMNAKMT2AMEN1PKM | |
| SCHEMBL932085 | 0.76 | SMN1; SMN2 (0.55) | LMNAKMT2AMEN1PKMSMN1; SMN2 | |
| SCHEMBL932591 | 0.76 | GAA (0.58) | ALDH1A1LMNAPOLBKMT2AMEN1 | |
| SCHEMBL16825800 | 0.75 | MEN1 (0.46) | KMT2AMEN1 | |
| SCHEMBL3830424 | 0.74 | POLB (0.80) | ALDH1A1LMNAPOLBPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448581-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002816-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | WO | disclosed |