Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10772061 | 0.95 | SIGMAR1 (0.38) | SIGMAR1HRH3LSSSLC6A4SLC6A3 | |
| SCHEMBL9322161 | 0.93 | HRH3 (0.41) | HRH3LSSSLC6A4 | |
| SCHEMBL9322145 | 0.93 | HRH3 (0.41) | HRH3LSSSLC6A4 | |
| SCHEMBL9322241 | 0.93 | HRH3 (0.45) | SIGMAR1HRH3LSSSLC6A4 | |
| SCHEMBL9324674 | 0.92 | HRH3 (0.38) | SIGMAR1HRH3LSSSLC6A4 | |
| SCHEMBL10774443 | 0.89 | HRH3 (0.48) | SIGMAR1HRH3LSSSLC6A4 | |
| SCHEMBL9322230 | 0.89 | HRH3 (0.48) | SIGMAR1HRH3LSSSLC6A4 | |
| SCHEMBL10774584 | 0.88 | HRH3 (0.42) | HRH3LSSSLC6A4 | |
| SCHEMBL9324566 | 0.88 | HRH3 (0.52) | SIGMAR1HRH3SLC6A4 | |
| SCHEMBL9321363 | 0.88 | HRH3 (0.42) | HRH3LSSSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310902-A | Glutamate blockers | NIPPON CHEMIPHAR CO., LTD. (JP) | 1994-05-10 | — | — | US | disclosed |
| EP-0235942-B1 | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO (JP) | 1994-03-23 | — | — | EP | disclosed |
| US-5070196-A | GLUTAMATE BLOCKERS | NIPPON CHEMIPHAR CO., LTD. (JP) | 1991-12-03 | — | — | US | disclosed |
| EP-0235942-A1 | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO., LTD. (JP) | 1987-09-09 | — | — | EP | disclosed |