Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | PKM | P14618 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | TYR | P14679 | 3/20 | 0.55 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9322706 | 1.00 | EGFR (0.74) | EGFRPOLBL3MBTL1KDM4EALDH1A1 | |
| Erbstatin SCHEMBL9320673 | 0.85 | ALDH1A1 (1.00) | EGFRPOLBL3MBTL1KDM4EALDH1A1 | |
| Erbstatin SCHEMBL9320680 | 0.85 | ALDH1A1 (1.00) | EGFRPOLBL3MBTL1KDM4EALDH1A1 | |
| Erbstatin SCHEMBL28061341 | 0.85 | ALDH1A1 (1.00) | EGFRPOLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1822010 | 0.77 | TYR (0.75) | POLBL3MBTL1TYRSYNJ2TTR | |
| SCHEMBL1822012 | 0.77 | TYR (0.75) | POLBL3MBTL1TYRSYNJ2TTR | |
| SCHEMBL9320061 | 0.77 | MAPT (0.62) | EGFRPOLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL9320066 | 0.77 | MAPT (0.62) | EGFRPOLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL9731308 | 0.76 | MAPT (0.56) | EGFRPOLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL9730856 | 0.75 | MAPT (0.60) | EGFRPOLBL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440887-B1 | Improvement in the total synthesis of Erbstatin analogs | ERBA CARLO SPA (IT) | 1994-01-26 | — | — | EP | disclosed |
| US-5130472-A | TOTAL SYNTHESIS OF ERBSTATIN ANALOGS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-07-14 | — | — | US | disclosed |
| EP-0440887-A1 | Improvement in the total synthesis of Erbstatin analogs | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-14 | — | — | EP | disclosed |