Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9592808 | 0.75 | HTR1A (0.48) | HTR1AKDM4ESLC6A4MTNR1ASTIM1 | |
| SCHEMBL8544064 | 0.72 | HTR1A (0.51) | HTR1ASLC6A4 | |
| SCHEMBL9326100 | 0.71 | HTR1A (0.51) | HTR1ASLC6A4 | |
| SCHEMBL9326213 | 0.70 | HTR1A (0.47) | HTR1ASLC6A4 | |
| SCHEMBL9444705 | 0.69 | HTR1A (0.64) | HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL9323890 | 0.69 | HTR1A (0.64) | HTR1ASLC6A4 | |
| SCHEMBL25403214 | 0.68 | CYP11B1 (0.39) | HTR1AKDM4E | |
| SCHEMBL8443740 | 0.67 | HTR1A (0.52) | HTR1ASLC6A4 | |
| SCHEMBL6964024 | 0.66 | HTR1A (1.00) | HTR1A | |
| SCHEMBL6964022 | 0.66 | HTR1A (1.00) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292761-A | Piperidine, tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-03-08 | — | — | US | disclosed |
| US-5278185-A | Piperidine, Tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5250544-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-10-05 | — | — | US | disclosed |
| US-5242933-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-09-07 | — | — | US | disclosed |
| US-5240942-A | Hypotensive agents; 5-hydroxytryptamine antagonist | ADIR ET COMPAGNIE (FR) | 1993-08-31 | — | — | US | disclosed |