Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.55 |
| ▸ | RARB | P10826 | 5/20 | 0.55 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | PPARD | Q03181 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326057 | 0.90 | PLA2G2A (0.74) | PLA2G2ARARB | |
| SCHEMBL9325195 | 0.88 | NR4A2 (0.59) | PKMMEN1KMT2APLA2G2AHDAC1 | |
| SCHEMBL9324868 | 0.85 | MAPT (0.61) | PLA2G2AHDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL8086185 | 0.85 | PKM (0.79) | PKMRARB | |
| SCHEMBL9323885 | 0.84 | MEN1 (0.82) | PKMMEN1KMT2A | |
| SCHEMBL9324842 | 0.83 | PLA2G2A (0.58) | PKMMEN1KMT2APLA2G2A | |
| SCHEMBL9325012 | 0.82 | RXRA (0.56) | PKMMEN1KMT2APLA2G2A | |
| SCHEMBL7315727 | 0.81 | PKM (0.79) | PKMHDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2673722 | 0.81 | PKM (0.72) | PKMMEN1KMT2APLA2G2A | |
| SCHEMBL28529167 | 0.80 | PLA2G2A (0.67) | PKMMEN1KMT2APLA2G2ARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374772-A | Skin disorders, antiinflammatory agents, cardiovascular disorders | HOFFMANN-LAROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |