Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | PPARD | Q03181 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325774 | 0.89 | MAPT (0.55) | MAPTRAB9AHDAC1HDAC2ALDH1A1 | |
| SCHEMBL7317665 | 0.87 | MAPT (0.82) | MAPTRAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL9323928 | 0.86 | LMNA (0.60) | MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL762838 | 0.86 | MAPT (0.55) | MAPTRAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL9323949 | 0.85 | PKM (0.57) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9325938 | 0.84 | KDM4E (0.54) | MAPTRAB9ATDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7826725 | 0.83 | MAPT (0.54) | MAPTRAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL7333166 | 0.82 | MAPT (0.79) | MAPTRAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL6539224 | 0.82 | MAPT (0.90) | MAPTRAB9ATDP1L3MBTL1NPC1 | |
| SCHEMBL9325175 | 0.81 | KMT2A (0.55) | MAPTRAB9APPARGNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374772-A | Skin disorders, antiinflammatory agents, cardiovascular disorders | HOFFMANN-LAROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |