Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.72 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | RARB | P10826 | 3/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9170809 | 0.85 | PLA2G2A (0.82) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL9324895 | 0.85 | PLA2G2A (0.51) | PLA2G2APLA2G4BTP53TSHRPTPN11 | |
| SCHEMBL7283625 | 0.85 | TP53 (0.77) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL7281514 | 0.85 | TP53 (0.77) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL7278960 | 0.85 | TP53 (0.77) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL5383674 | 0.85 | TP53 (0.77) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL5388136 | 0.85 | TP53 (0.77) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL14672324 | 0.85 | TP53 (0.77) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL9779326 | 0.85 | TP53 (0.77) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL7271669 | 0.85 | TP53 (0.77) | PLA2G2APLA2G4BTP53TSHRRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374772-A | Skin disorders, antiinflammatory agents, cardiovascular disorders | HOFFMANN-LAROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | disclosed |